Molecular structure of Epigenetic Multiple Ligand, CAS Number: 1020399-52-3
Epigenetic Multiple Ligand (CAS 1020399-52-3)
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Alternate Names:
PRMT Inhibitor IV
Application:
Epigenetic Multiple Ligand is a cell-permeable bis-arylidene compound
CAS Number:
1020399-52-3
Molecular Weight:
623.9
Molecular Formula:
C19H12Br4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Epigenetic Multiple Ligand is a cell-permeable bis-arylidene compound that acts as an epi-ML and inhibits substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1, with weak effect on the process of Np13p by PRMT1. Epigenetic Multiple Ligand may act to induce either apoptosis or granulocytic differentiation among U937 cell population. It is an inhibitor of PRMT.
Epigenetic Multiple Ligand (CAS 1020399-52-3) References
- epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. | Mai, A., et al. 2008. J Med Chem. 51: 2279-90. PMID: 18348515
- Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. | García, J., et al. 2011. Bioorg Med Chem. 19: 3637-49. PMID: 21215647
- Epigenetic multiple modulators. | Álvarez, R., et al. 2011. Curr Top Med Chem. 11: 2749-87. PMID: 22039877
- Targeting epigenetic networks with polypharmacology: a new avenue to tackle cancer. | Franci, G., et al. 2010. Epigenomics. 2: 731-42. PMID: 22122079
- Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities. | Pereira, R., et al. 2012. J Med Chem. 55: 9467-91. PMID: 23030799
Inhibitor of:
PRMT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Epigenetic Multiple Ligand, 10 mg | sc-221591 | 10 mg | $391.00 |