eotaxin-2 Antibody (NYRhEOT2): sc-73285
- eotaxin-2 Antibody (NYRhEOT2) is a mouse monoclonal IgG1 κ eotaxin-2 antibody provided at 100 µg/ml
- raised against recombinant eotaxin-2 of human origin
- recommended for detection of eotaxin-2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for eotaxin-2 Antibody (NYRhEOT2). This work is in progress.
eotaxin-2 Antibody (NYRhEOT2) is a mouse monoclonal IgG1 kappa light chain antibody that detects human eotaxin-2 by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-eotaxin-2 antibody (NYRhEOT2) is available as a non-conjugated format. Eotaxin-2, also known as MPIF-2, CK β-6, or small inducible cytokine A24, plays a crucial role in immune response by promoting chemotaxis and calcium mobilization of eosinophils through CCR3 receptor interaction. This chemokine is particularly important in allergic responses and asthma, as eotaxin-2 helps recruit eosinophils to sites of inflammation, thereby contributing to tissue remodeling and pathophysiology of these conditions. Notably, eotaxin-2 is distinct from eotaxin, sharing only 39% amino acid homology, and eotaxin-2 lacks suppressive activity against immature myeloid progenitor cells stimulated by various growth factors, highlighting a unique functional profile in the immune system.
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eotaxin-2 Antibody (NYRhEOT2) References:
- Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors. | Broxmeyer, HE., et al. 1999. Ann N Y Acad Sci. 872: 142-62; discussion 163. PMID: 10372118
- Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. | Kitaura, M., et al. 1999. J Biol Chem. 274: 27975-80. PMID: 10488147
- C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). | Ying, S., et al. 1999. J Immunol. 163: 3976-84. PMID: 10491000
- Endothelial and epithelial expression of eotaxin-2 (CCL24) in nasal polyps. | Schaefer, D., et al. 2006. Int Arch Allergy Immunol. 140: 205-14. PMID: 16682802
- Eotaxin-2 in sputum cell culture to evaluate asthma inflammation. | Scheicher, ME., et al. 2007. Eur Respir J. 29: 489-95. PMID: 17079258
- Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. | Patel, VP., et al. 1997. J Exp Med. 185: 1163-72. PMID: 9104803
- Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. | Forssmann, U., et al. 1997. J Exp Med. 185: 2171-6. PMID: 9182688
- Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. | White, JR., et al. 1997. J Leukoc Biol. 62: 667-75. PMID: 9365122
- Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophils. | Elsner, J., et al. 1998. Eur J Immunol. 28: 2152-8. PMID: 9692884
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
eotaxin-2 Antibody (NYRhEOT2) | sc-73285 | 100 µg/ml | $322.00 |