Endophilin I Antibody (H-8): sc-374278
- Endophilin I Antibody (H-8) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 267-303 near the C-terminus of Endophilin I of mouse origin
- recommended for detection of Endophilin I of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Endophilin I Antibody (H-8) for WB applications. These reagents are now offered in bundles with Endophilin I Antibody (H-8) (see ordering information below).
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Endophilin I Antibody (H-8) is a mouse monoclonal IgG1 antibody that detects Endophilin I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Endophilin I is a crucial member of the endophilin family, which plays a significant role in presynaptic vesicle trafficking at nerve terminals, a process essential for neurotransmitter release and synaptic communication. Endophilin I is primarily localized in the brain, where anti-Endophilin I antibody (H-8) can detect its involvement in modulating G protein-coupled receptor signaling by acting as an adapter protein that directs β1 adrenergic receptors to the endocytic machinery, thereby influencing receptor internalization and recycling. The unique expression pattern of Endophilin I underscores its specialized function in neuronal synapses, making Endophilin I (H-8) antibody an invaluable tool for researchers investigating the intricate mechanisms of synaptic transmission and molecular pathways involved in neurobiology.
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Endophilin I Antibody (H-8) References:
- Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. | Schmidt, A., et al. 1999. Nature. 401: 133-41. PMID: 10490020
- Differential expression of endophilin 1 and 2 dimers at central nervous system synapses. | Ringstad, N., et al. 2001. J Biol Chem. 276: 40424-30. PMID: 11518713
- Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. | Anggono, V. and Robinson, PJ. 2007. J Neurochem. 102: 931-43. PMID: 17437541
- Endophilin I expression is increased in the brains of Alzheimer disease patients. | Ren, Y., et al. 2008. J Biol Chem. 283: 5685-91. PMID: 18167351
- Proteome-wide inference of human endophilin 1-binding peptides. | Wu, G., et al. 2012. Protein Pept Lett. 19: 1094-102. PMID: 22512650
- Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2 pathway. | Liu, W., et al. 2014. Brain Res. 1573: 17-26. PMID: 24854121
- Endophilin-1 regulates blood-brain barrier permeability via EGFR-JNK signaling pathway. | Chen, L., et al. 2015. Brain Res. 1606: 44-53. PMID: 25721793
- MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1. | Liu, W., et al. 2016. Exp Cell Res. 343: 248-257. PMID: 27038654
- The role of LINC00094/miR-224-5p (miR-497-5p)/Endophilin-1 axis in Memantine mediated protective effects on blood-brain barrier in AD microenvironment. | Zhu, L., et al. 2019. J Cell Mol Med. 23: 3280-3292. PMID: 30801976
- Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β. | Yin, Y., et al. 2019. Mol Med Rep. 19: 4897-4905. PMID: 31059028
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Endophilin I Antibody (H-8) | sc-374278 | 200 µg/ml | $316.00 | |||
Endophilin I Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-540430 | 200 µg Ab; 10 µg BP | $354.00 | |||
Endophilin I Antibody (H-8): m-IgG1 BP-HRP Bundle | sc-542116 | 200 µg Ab; 20 µg BP | $354.00 | |||
Endophilin I (H-8) Neutralizing Peptide | sc-374278 P | 100 µg/0.5 ml | $68.00 |