E-Selectin/CD62E/SELE Antibody (D-7): sc-137054

E-Selectin Antibody (D-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects E-Selectin of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-E-Selectin antibody (D-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. E-Selectin, also known as ELMA-1 or CD62E, plays a crucial role in the immune response by mediating the adhesion of leukocytes to the vascular endothelium during inflammation. E-Selectin is primarily expressed on cytokine-stimulated endothelial cells, where E-Selectin facilitates the recruitment of immune cells to sites of injury or infection, thereby contributing to the inflammatory process. The ability of E-Selectin to interact with specific carbohydrates on leukocytes is vital for the regulation of immune responses, making E-Selectin an important target for research in inflammation and related diseases. E-Selectin monoclonal antibody (D-7) is an essential tool for studying these processes in various experimental settings, providing insights into the mechanisms of leukocyte trafficking and the pathophysiology of inflammatory conditions.

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E-Selectin/CD62E/SELE Antibody (D-7) References:

1. Species-specific and conserved epitopes on mouse and human E-selectin important for leukocyte adhesion.  |  Hammel, M., et al. 2001. Exp Cell Res. 269: 266-74. PMID: 11570819
2. E-selectin and L-selectin polymorphisms in patients with periodontitis.  |  Houshmand, B., et al. 2009. J Periodontal Res. 44: 88-93. PMID: 18973547
3. Selectin ligands.  |  Varki, A. 1994. Proc Natl Acad Sci U S A. 91: 7390-7. PMID: 7519775
4. Leukocyte trafficking mediated by selectin-carbohydrate interactions.  |  McEver, RP., et al. 1995. J Biol Chem. 270: 11025-8. PMID: 7538108
5. The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via alpha-actinin: receptor positioning in microvilli does not require interaction with alpha-actinin.  |  Pavalko, FM., et al. 1995. J Cell Biol. 129: 1155-64. PMID: 7538138
6. The selectins: vascular adhesion molecules.  |  Tedder, TF., et al. 1995. FASEB J. 9: 866-73. PMID: 7542213
7. Selectin-carbohydrate interactions and the initiation of the inflammatory response.  |  Lasky, LA. 1995. Annu Rev Biochem. 64: 113-39. PMID: 7574477
8. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins.  |  Frenette, PS., et al. 1996. Cell. 84: 563-74. PMID: 8598043
9. Platelet-mediated lymphocyte delivery to high endothelial venules.  |  Diacovo, TG., et al. 1996. Science. 273: 252-5. PMID: 8662511
10. Two selectins converge on sulphate. Leukocyte adhesion.  |  Rosen, SD. and Bertozzi, CR. 1996. Curr Biol. 6: 261-4. PMID: 8805242
11. E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis.  |  Engelhardt, B., et al. 1997. Blood. 90: 4459-72. PMID: 9373256
12. T cell interaction with ICAM-1-deficient endothelium in vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells.  |  Reiss, Y., et al. 1998. Eur J Immunol. 28: 3086-99. PMID: 9808177

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-E-Selectin/CD62E/SELE Antibody (D-7) has 35 citations in a variety of scientific publications.

Primary antibodies like Anti-E-Selectin/CD62E/SELE Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

E-Selectin/CD62E/SELE Antibody (D-7) Specifications

Alternate Product Name: Selectin E

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 311-610

Epitope Target: E-Selectin

Epitope Species: human

Product Reactivity/Detection: E-Selectin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 35 citations in various scientific publications

Available Conjugates/Forms for E-Selectin/CD62E/SELE Antibody (D-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin