DUX3 Antibody (6L8): sc-134322
- DUX3 Antibody (6L8) is a mouse monoclonal IgG2b κ DUX3 antibody provided at 100 µg/ml
- raised against recombinant DUX3 protein of human origin
- recommended for detection of DUX3 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DUX3 Antibody (6L8). This work is in progress.
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DUX3 Antibody (6L8) is a mouse monoclonal IgG2b kappa light chain antibody that detects DUX3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). DUX3 (6L8) antibody is available as a non-conjugated format. DUX3 protein belongs to the double homeobox (DUX) family, which plays a crucial role in early embryonic development and cellular differentiation. DUX3 regulates gene expression during pluripotent stem cell formation, making DUX3 essential for proper developmental processes. DUX family members, including DUX1, DUX2, DUX3, DUX4, and DUX5, contain homeobox domains that facilitate DNA binding and transcriptional regulation. DUX3 shares high sequence identity with DUX1 and DUX5, highlighting evolutionary conservation of function. Additional start sites in DUX3 and DUX5 genes produce N-terminal extended isoforms, diversifying functional roles. DUX3 dysregulation has been implicated in various developmental disorders and diseases, including certain muscular dystrophies.
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DUX3 Antibody (6L8) References:
- Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. | Gabriëls, J., et al. 1999. Gene. 236: 25-32. PMID: 10433963
- Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. | Beckers, M., et al. 2001. Gene. 264: 51-7. PMID: 11245978
- Intracellular trafficking and dynamics of double homeodomain proteins. | Ostlund, C., et al. 2005. Biochemistry. 44: 2378-84. PMID: 15709750
- Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development. | Kawazu, M., et al. 2007. J Immunol. 179: 5335-45. PMID: 17911620
- DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. | Dixit, M., et al. 2007. Proc Natl Acad Sci U S A. 104: 18157-62. PMID: 17984056
- Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements. | Ding, H., et al. 1998. Hum Mol Genet. 7: 1681-94. PMID: 9736770
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DUX3 Antibody (6L8) | sc-134322 | 100 µg/ml | $339.00 |