Date published: 2026-1-8
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DuP-697 (CAS 88149-94-4) - chemical structure image
Molecular structure of DuP-697, CAS Number: 88149-94-4
DuP-697 (CAS 88149-94-4) - chemical structure image
Molecular structure of DuP-697, CAS Number: 88149-94-4
DuP-697: sc-200680. Western blot analysis of Cox-2 expression in untreated (A) and DuP-697 treated (B) A549 whole cell lys
DuP-697: sc-200680. Western blot analysis of Cox-2 expression in untreated (A) and DuP-697 treated (B) A549 whole cell lysates. Note down regulation of Cox-2 expression in lane B. Antibody tested: Cox-2 (C-20): sc-1745.
DuP-697: sc-200680. Western blot analysis of Cox-2 expression in untreated (A) and DuP-697 treated (B) A549 whole cell lys
DuP-697: sc-200680. Western blot analysis of Cox-2 expression in untreated (A) and DuP-697 treated (B) A549 whole cell lysates. Note down regulation of Cox-2 expression in lane B. Antibody tested: Cox-2 (M-19): sc-1747.
Molecular structure of DuP-697, CAS Number: 88149-94-4

DuP-697 (CAS 88149-94-4)

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Alternate Names:
5-bromo-2-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-thiophene
Application:
DuP-697 is a thiophene that inhibits Cox-2
CAS Number:
88149-94-4
Purity:
≥98%
Molecular Weight:
411.3
Molecular Formula:
C17H12BrFO2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

DuP-697 is a chemical compound used primarily in the research of enzyme inhibition, specifically targeting the cyclooxygenase-2 (COX-2) enzyme. It serves as useful for scientists exploring the regulation of prostaglandin synthesis, as COX-2 is a key enzyme involved in the conversion of arachidonic acid to prostaglandins. By inhibiting COX-2, DuP-697 allows researchers to study the role of this enzyme in various biological processes, including inflammation and cell signaling. In addition, DuP-697 is utilized in research to understand the differential effects between COX-1 and COX-2 enzymes, since it is a selective inhibitor. The compound′s selectivity aids in dissecting the distinct physiological functions and contributions of each COX isoform.


DuP-697 (CAS 88149-94-4) References

  1. PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity.  |  Rosenstock, M., et al. 1999. Biochim Biophys Acta. 1440: 127-37. PMID: 10477832
  2. Prenatal effects of DuP-697-the irreversible, highly selective cyclooxygenase-2 inhibitor.  |  Burdan, F., et al. 2003. Reprod Toxicol. 17: 413-9. PMID: 12849852
  3. Inhibition of angiogenic tubule formation and induction of apoptosis in human endothelial cells by the selective cyclooxygenase-2 inhibitor 5-bromo-2-(4-fluorophenyl)-3-(methylsulfonyl) thiophene (DuP-697).  |  Churchman, A., et al. 2007. Eur J Pharmacol. 573: 176-83. PMID: 17643408
  4. Dup-697, a specific COX-2 inhibitor, suppresses growth and induces apoptosis on K562 leukemia cells by cell-cycle arrest and caspase-8 activation.  |  Peng, HL., et al. 2008. Ann Hematol. 87: 121-9. PMID: 17999062
  5. Roles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor.  |  Choi, CH., et al. 2010. Korean J Pain. 23: 236-41. PMID: 21217886
  6. Roles of serotonergic and adrenergic receptors in the antinociception of selective cyclooxygenase-2 inhibitor in the rat spinal cord.  |  Jeong, HJ., et al. 2011. Korean J Pain. 24: 179-84. PMID: 22220238
  7. Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697.  |  Agarwal, V., et al. 2013. Int J Oncol. 42: 1088-92. PMID: 23338544
  8. Pharmacology of cannabinoid receptor agonists and a cyclooxygenase-2 inhibitor in rat bone tumor pain.  |  Cui, JH., et al. 2013. Pharmacology. 92: 150-7. PMID: 24008428
  9. Anticancer effect of COX-2 inhibitor DuP-697 alone and in combination with tyrosine kinase inhibitor (E7080) on colon cancer cell lines.  |  Altun, A., et al. 2014. Asian Pac J Cancer Prev. 15: 3113-21. PMID: 24815456
  10. Effects of a Multikinase Inhibitor Motesanib (AMG 706) Alone and Combined with the Selective DuP-697 COX-2 Inhibitor on Colorectal Cancer Cells.  |  Kaya, TT., et al. 2016. Asian Pac J Cancer Prev. 17: 1103-10. PMID: 27039732
  11. Nanocluster-assisted protein-film voltammetry for direct electrochemical signal acquisition.  |  Li, W., et al. 2021. Anal Bioanal Chem. 413: 1665-1673. PMID: 33501552
  12. Simultaneous quantification of an anti-inflammatory compound (DuP 697) and a potential metabolite (X6882) in human plasma and urine by high-performance liquid chromatography.  |  Joshi, AS., et al. 1994. J Chromatogr B Biomed Appl. 660: 143-50. PMID: 7858707
  13. Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney.  |  Seibert, K., et al. 1996. Br J Pharmacol. 117: 1016-20. PMID: 8882591

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DuP-697, 5 mg

sc-200680
5 mg
$150.00

DuP-697, 25 mg

sc-200680A
25 mg
$500.00
1-800-457-3801
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