DR5 (h): 293 Lysate: sc-110563

The DR5 (h): 293 Lysate is derived from the HEK293 cell line, a human embryonic kidney cell line frequently utilized in cell biology and molecular research due to its reliable growth and high transfection efficiency. This lysate contains Death Receptor 5 (DR5), a member of the tumor necrosis factor receptor superfamily, which plays a critical role in apoptotic signaling pathways. DR5, also known as TRAIL receptor 2, binds to the TNF-related apoptosis-inducing ligand (TRAIL), leading to the formation of the death-inducing signaling complex (DISC). This complex subsequently activates caspase-8, initiating a cascade that results in apoptosis. In scientific research, DR5 (h): 293 Lysate is used to investigate the mechanisms of apoptosis and the signaling pathways involved in programmed cell death. It is particularly valuable in studying the interactions between DR5 and its ligands, the formation and function of the DISC, and the downstream effects on caspase activation. Researchers employ this lysate in in vitro assays to analyze protein-protein interactions, post-translational modifications, and the regulatory processes affecting DR5-mediated signaling. Additionally, the lysate is used in screening assays to identify potential modulators of DR5 activity, providing insights into the regulation of apoptotic processes and cellular responses to stress.