Molecular structure of Dothiepin, CAS Number: 113-53-1
Dothiepin (CAS 113-53-1)
Alternate Names:
3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine; N,N-Dimethyl- dibenzo[b,e]thiepin-11(6H),γ-propylamine; Dosulepin
Application:
Dothiepin is a serotonin and norepinephrine reuptake inhibitor
CAS Number:
113-53-1
Molecular Weight:
295.44
Molecular Formula:
C19H21NS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Dothiepin is a tricyclic inhibitor of serotonin and norepinephrine reuptake. Dothiepin is described to have equipotent serotonin and norepinephrine reuptake inhibition activity. It inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft back into the presynaptic neuron. This inhibition leads to an increased concentration of these neurotransmitters in the synaptic gap, allowing them to exert a greater effect on post-synaptic receptors. Beyond its effects on serotonin and norepinephrine reuptake, Dothiepin also exhibits affinity for adrenergic, histamine, and muscarinic acetylcholine receptors, which can contribute to its overall biochemical effects.
Dothiepin (CAS 113-53-1) References
- Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. | Sánchez, C. and Hyttel, J. 1999. Cell Mol Neurobiol. 19: 467-89. PMID: 10379421
- Fatal intoxication due to dothiepin. | Keller, T., et al. 2000. Forensic Sci Int. 109: 159-66. PMID: 10704818
- Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids. | Sen, T., et al. 2000. Life Sci. 66: PL325-30. PMID: 10855953
- The excretion of dothiepin and its primary metabolites in breast milk. | Ilett, KF., et al. 1992. Br J Clin Pharmacol. 33: 635-9. PMID: 1389937
- [PHARMACOLOGICAL PROPERTIES OF 6,11-DIHYDRODIBENZ(B,E)THIEPIN DERIVATIVES. 1]. | METYSOVA, J., et al. 1963. Arzneimittelforschung. 13: 1039-43. PMID: 14208672
- Toxicokinetics of dothiepin: 2 case reports. | Roelofsen, EE., et al. 2008. Ther Drug Monit. 30: 638-41. PMID: 18695634
- Dothiepin-induced transient hypomania and extrapyramidal syndrome. | Inamdar, A., et al. 2013. Indian J Psychiatry. 55: 383-5. PMID: 24459312
- Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials. | Hayasaka, Y., et al. 2015. J Affect Disord. 180: 179-84. PMID: 25911132
- Dothiepin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. | Lancaster, SG. and Gonzalez, JP. 1989. Drugs. 38: 123-47. PMID: 2670509
- Spectroscopic, electrochemical and molecular docking studies of dothiepin and doxepin with bovine serum albumin and DNA base. | Rajendiran, N. and Thulasidhasan, J. 2016. Luminescence. 31: 1438-1447. PMID: 26991906
- Blood and plasma concentrations of dothiepin and its major metabolites and clinical response. | Maguire, KP., et al. 1982. J Affect Disord. 4: 41-8. PMID: 6461686
- Clinical pharmacokinetics of dothiepin. Single-dose kinetics in patients and prediction of steady-state concentrations. | Maguire, KP., et al. 1983. Clin Pharmacokinet. 8: 179-85. PMID: 6851370
- Metabolism and pharmacokinetics of dothiepin. | Maguire, KP., et al. 1981. Br J Clin Pharmacol. 12: 405-9. PMID: 7295471
- The tolerability of dothiepin: a review of clinical studies between 1963 and 1990 in over 13,000 depressed patients. | Donovan, S., et al. 1994. Prog Neuropsychopharmacol Biol Psychiatry. 18: 1143-62. PMID: 7846285
- Greater toxicity in overdose of dothiepin than of other tricyclic antidepressants. | Buckley, NA., et al. 1994. Lancet. 343: 159-62. PMID: 7904010
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dothiepin, 5 mg | sc-211377 | 5 mg | $367.00 |