Molecular structure of Domperidone, CAS Number: 57808-66-9
Domperidone (CAS 57808-66-9)
See product citations (2)
Application:
Domperidone is a peripheral D2DR inhibitor
CAS Number:
57808-66-9
Purity:
≥99%
Molecular Weight:
425.91
Molecular Formula:
C22H24ClN5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Domperidone is a dopamine receptor antagonist that functions by blocking the action of dopamine at the D2 and D3 receptor sites. It blocks the inhibitory effects of dopamine on the release of acetylcholine, which in turn stimulates the contraction of smooth muscle. This action is involved in enhancing gastrointestinal motility and optimizing the coordination of various digestive processes. In research applications, this property of domperidone is studied to understand and model the regulatory pathways involved in gastrointestinal functions. It helps elucidate the complex interplay of neurotransmitters and their receptors in the control of digestive mechanisms.
Domperidone (CAS 57808-66-9) References
- Domperidone: a peripherally acting dopamine2-receptor antagonist. | Barone, JA. 1999. Ann Pharmacother. 33: 429-40. PMID: 10332535
- Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. | Osinski, MA., et al. 2005. Pharmacol Biochem Behav. 81: 211-9. PMID: 15894081
- A systematic review of the efficacy of domperidone for the treatment of diabetic gastroparesis. | Sugumar, A., et al. 2008. Clin Gastroenterol Hepatol. 6: 726-33. PMID: 18524689
- The dual role of domperidone in gastroparesis and lactation. | Phan, H., et al. 2014. Int J Pharm Compd. 18: 203-7. PMID: 25306766
- Domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants: a systematic review and meta-analysis. | Grzeskowiak, LE., et al. 2018. BJOG. 125: 1371-1378. PMID: 29469929
- Domperidone treatment attenuates stress-induced suppression of reproduction in viviparous mosquitofish Gambusia affinis. | Bhat, SK. and Ganesh, CB. 2020. J Fish Biol. 96: 37-48. PMID: 31648360
- Piperine phytosomes for bioavailability enhancement of domperidone. | Islam, N., et al. 2022. J Liposome Res. 32: 172-180. PMID: 33944662
- A dopamine antagonist, domperidone enhances the replication of an oncolytic adenovirus in human tumour cells. | Nishimae, F., et al. 2022. J Gen Virol. 103: PMID: 35731650
- Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells. | Aoyama, M., et al. 2022. J Biol Chem. 298: 102635. PMID: 36273581
- Psychiatric Manifestations of Withdrawal Following Domperidone Used as a Galactagogue. | Majdinasab, E., et al. 2022. Breastfeed Med. 17: 1018-1024. PMID: 36367713
- Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic. | Brogden, RN., et al. 1982. Drugs. 24: 360-400. PMID: 6756878
- The antiemetic effects of domperidone, a novel potent gastrokinetic. | Niemegeers, CJ., et al. 1980. Arch Int Pharmacodyn Ther. 244: 130-40. PMID: 7416883
- Domperidone. A review of its use in diabetic gastropathy. | Prakash, A. and Wagstaff, AJ. 1998. Drugs. 56: 429-45. PMID: 9777316
Inhibitor of:
D2DR, D5DR, Dopamine, EG668210, GPR162, motilin, Olr401, Placental lactogen I, PLP-A, Prolactin, Vmn2r34, and VN1R2.Activator of:
PLP-J.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Domperidone, 50 mg | sc-203032 | 50 mg | $60.00 | |||
Domperidone, 250 mg | sc-203032A | 250 mg | $281.00 |