DNPEP Antibody (Q-16): sc-100492

DNPEP Antibody (Q-16) is a mouse monoclonal IgG1 kappa light chain antibody that detects DNPEP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DNPEP antibody (Q-16) is available as the non-conjugated monoclonal isotype antibody. DNPEP, also known as DAP, ASPEP, or aspartyl aminopeptidase, is a 475 amino acid protein belonging to the M18 family of the MH clan of co-catalytic metallopeptidases. DNPEP features three zinc finger binding domains and several conserved residues, including three histidines, three glutamates, and five aspartates, which are crucial for enzymatic activity. DNPEP is widely expressed throughout the body, with highest levels found in the testis, intermediate levels in the kidney and lung, and notable expression in the spleen, liver, and brain. One of the key functions of DNPEP is removing glutamyl or aspartyl residues from the N-terminal of acidic amino acid-containing peptides, highlighting significance in intracellular protein and peptide metabolism. In the brain, DNPEP plays a vital role in converting Angiotensin I to Angiotensin II, which is essential for regulating blood pressure. This function suggests that DNPEP may serve as a potential target for antihypertensive therapy, making DNPEP an important protein for both physiological regulation and therapeutic intervention.

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DNPEP Antibody (Q-16) References:

1. Comparative distribution of glutamyl and aspartyl aminopeptidase activities in mouse organs.  |  Ramírez-Expósito, MJ., et al. 2000. Horm Metab Res. 32: 161-3. PMID: 10871154
2. Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase.  |  Wilk, S., et al. 2002. Arch Biochem Biophys. 407: 176-83. PMID: 12413488
3. Effects of changes in hydromineral balance on rat brain aspartyl, arginyl, and alanyl aminopeptidase activities.  |  Varona, A., et al. 2003. Horm Metab Res. 35: 36-42. PMID: 12669269
4. Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells.  |  Yokoyama, R., et al. 2006. FEBS J. 273: 192-8. PMID: 16367759
5. Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.  |  Carrera, MP., et al. 2006. Cancer Invest. 24: 149-53. PMID: 16537183
6. Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma.  |  Varona, A., et al. 2007. Am J Physiol Renal Physiol. 292: F780-8. PMID: 16985214
7. Brain aminopeptidases and hypertension.  |  Banegas, I., et al. 2006. J Renin Angiotensin Aldosterone Syst. 7: 129-34. PMID: 17094048
8. The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.  |  Teuscher, F., et al. 2007. J Biol Chem. 282: 30817-26. PMID: 17720817
9. Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase.  |  Wilk, S., et al. 1998. J Biol Chem. 273: 15961-70. PMID: 9632644

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DNPEP Antibody (Q-16) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DNPEP Antibody (Q-16) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DNPEP Antibody (Q-16) Specifications

Alternate Product Name: DNPEP

Product Clone Name: Q-16

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-476

Epitope Target: DNPEP

Epitope Species: human

Product Reactivity/Detection: DNPEP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DNPEP Antibody (Q-16): N/A