Molecular structure of DK-AH 269, CAS Number: 186097-54-1
DK-AH 269 (CAS 186097-54-1)
Alternate Names:
Cilobradine hydrochloride
Application:
DK-AH 269 is An HCN Channel blocker
CAS Number:
186097-54-1
Purity:
≥98%
Molecular Weight:
519.07
Molecular Formula:
C28H38N2O5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
DK-AH 269 (CAS 186097-54-1) References
Van Bogaert, P.P., and Pittoors, F., Use-dependent blockage of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur. J. Pharmacol. 478, 161-171, (2003) Chevaleyre, V., and Castillo, P.E., Assessing the role of Ih channels in synaptic transmission and mossy fiber LTP. Proc. Natl. Acad. Sci. U. S. A. 99, 9538-9543, (2002) Raes, A., et al., Use-dependent block of Ih in mouse dorsal root ganglion neurons by sinus node inhibitors. Br. J. Pharmacol. 125, 741-750, (1998) Pape, H.C., Specific bradycardic agents block the hyperpolarization-activated cation current in central neurons. Neuroscience 59, 363-373, (1994) Stieber, J., et al., Bradycardic and proarrhythmic properties of sinus node inhibitors Mol. Pharmacol. 69, 1328-1337, (2006)Inhibitor of:
HCN4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DK-AH 269, 5 mg | sc-252761 | 5 mg | $180.00 |