Molecular structure of Dimethyl-W84 dibromide, CAS Number: 402475-33-6
Dimethyl-W84 dibromide (CAS 402475-33-6)
Alternate Names:
N,N′-Bis[3-(1,3-dihydro-5-methyl-1,3-dioxo-2H-isoindol-2-yl)propyl]-N,N,N′,N′-tetramethyl-1,6-hexanediamminium dibromide
Application:
Dimethyl-W84 dibromide is a potent allosteric modulator of muscarinic receptors also selective for M2-receptors
CAS Number:
402475-33-6
Purity:
98%
Molecular Weight:
736.58
Molecular Formula:
C34H48Br2N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dimethyl-W84 dibromide is a very potent allosteric modulator of muscarinic receptors, selective for M2-receptors. Dimethyl-W84 dibromide retards the dissociation of the antagonist N-methylscopolamine. pKA=7.08, p(alphaKA)=6.75, pEC50,diss=6.77.
Dimethyl-W84 dibromide (CAS 402475-33-6) References
- Hexamethonium-type allosteric modulators of the muscarinic receptors bearing lateral dibenzazepine moieties. | Li, R., et al. 2001. Arch Pharm (Weinheim). 334: 121-4. PMID: 11382147
- Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors. | Voigtländer, U., et al. 2003. Mol Pharmacol. 64: 21-31. PMID: 12815157
- Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors. | Tränkle, C., et al. 2003. Mol Pharmacol. 64: 180-90. PMID: 12815174
- Contribution of lateral substituents in symmetrical and non-symmetrical heptane-bisammonio compounds to the allosteric stabilization of N-methylscopolamine binding to muscarinic M2 receptors. | Staudt, M., et al. 2003. Arch Pharm (Weinheim). 336: 385-9. PMID: 14502759
- Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors. | Tränkle, C., et al. 2005. Mol Pharmacol. 68: 1597-610. PMID: 16157694
- Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors. | Tränkle, C., et al. 1998. Mol Pharmacol. 54: 139-45. PMID: 9658199
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dimethyl-W84 dibromide, 5 mg | sc-202140 | 5 mg | $92.00 |