Molecular structure of Dihydrocapsiate
Dihydrocapsiate (CAS 205687-03-2)
Alternate Names:
8-Methylnonanoic Acid (4-Hydroxy-3-methoxyphenyl)methyl Ester; 4-Hydroxy-3-methoxybenzyl 8-methylnonanoate
CAS Number:
205687-03-2
Molecular Weight:
308.41
Molecular Formula:
C18H28O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Dihydrocapsiate is a compound found in chili peppers that is used in research on metabolism and energy expenditure. It is structurally related to capsaicin but is non-pungent, which makes it a subject of interest in studies investigating the effects of capsinoids on fat oxidation and thermogenesis. In nutritional research, dihydrocapsiate is examined for its potential to affect metabolic rate. Additionally, it is used in studies exploring the regulation of lipid metabolism and the mechanisms by which dietary compounds can influence metabolic pathways. Research on dihydrocapsiate also includes its role in the activation of transient receptor potential (TRP) channels, which are involved in sensing temperature and flavor.
Dihydrocapsiate (CAS 205687-03-2) References
- Enzymatic synthesis of a capsinoid by the acylation of vanillyl alcohol with fatty acid derivatives catalyzed by lipases. | Kobata, K., et al. 2002. Biosci Biotechnol Biochem. 66: 319-27. PMID: 11999404
- Studies of the toxicological potential of capsinoids: V. Genotoxicity studies of dihydrocapsiate. | Bernard, BK., et al. 2008. Int J Toxicol. 27 Suppl 3: 59-72. PMID: 19037799
- Studies of the toxicological potential of capsinoids: VI. Single-dose toxicity study and micronucleus test of commercial-grade dihydrocapsiate. | Watanabe, E., et al. 2008. Int J Toxicol. 27 Suppl 3: 73-7. PMID: 19037800
- Studies of the toxicological potential of capsinoids: VIII. A 13-week toxicity study of commercial-grade dihydrocapsiate in rats. | Watanabe, E., et al. 2008. Int J Toxicol. 27 Suppl 3: 101-18. PMID: 19037802
- Studies of the toxicological potential of capsinoids: IX. Teratology studies of dihydrocapsiate in rats and rabbits. | Bernard, BK., et al. 2008. Int J Toxicol. 27 Suppl 3: 119-36. PMID: 19037803
- Determination of capsinoids by HPLC-DAD in capsicum species. | Singh, S., et al. 2009. J Agric Food Chem. 57: 3452-7. PMID: 19415923
- Assessment of the biological similarity of three capsaicin analogs (Capsinoids) found in non-pungent chili pepper (CH-19 Sweet) fruits. | Sasahara, I., et al. 2010. Biosci Biotechnol Biochem. 74: 274-8. PMID: 20139632
- Studies of the toxicological potential of capsinoids XIV: a 26-week gavage toxicity study of dihydrocapsiate in rats. | Kodama, T., et al. 2010. Int J Toxicol. 29: 27S-54S. PMID: 20388822
- Effects of dihydrocapsiate on adaptive and diet-induced thermogenesis with a high protein very low calorie diet: a randomized control trial. | Lee, TA., et al. 2010. Nutr Metab (Lond). 7: 78. PMID: 20925950
- Relationship between the acyl chain length of paradol analogues and their antiobesity activity following oral ingestion. | Haratake, A., et al. 2014. J Agric Food Chem. 62: 6166-74. PMID: 24909840
- Practical large-scale production of dihydrocapsiate, a nonpungent capsaicinoid-like substance. | Kurosawa, W., et al. 2017. Biosci Biotechnol Biochem. 81: 211-221. PMID: 27838955
- Dihydrocapsiate improved age-associated impairments in mice by increasing energy expenditure. | Ohyama, K. and Suzuki, K. 2017. Am J Physiol Endocrinol Metab. 313: E586-E597. PMID: 28811294
- Thermogenic Blend Alone or in Combination with Whey Protein Supplement Stimulates Fat Metabolism and Improves Body Composition in Mice. | Vieira-Brock, PL., et al. 2018. Pharmacognosy Res. 10: 37-43. PMID: 29568185
- Dihydrocapsiate supplementation prevented high-fat diet-induced adiposity, hepatic steatosis, glucose intolerance, and gut morphological alterations in mice. | Baboota, RK., et al. 2018. Nutr Res. 51: 40-56. PMID: 29673543
- Quantitation of capsiate and dihydrocapsiate and tentative identification of minor capsinoids in pepper fruits (Capsicum spp.) by HPLC-ESI-MS/MS(QTOF). | Fayos, O., et al. 2019. Food Chem. 270: 264-272. PMID: 30174045
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dihydrocapsiate, 10 mg | sc-500977 | 10 mg | $306.00 |