Date published: 2026-1-20

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Diclosulam (CAS 145701-21-9)

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Alternate Names:
N-(2,6-Dichlorophenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide
Application:
Diclosulam is a broadleaf herbicide
CAS Number:
145701-21-9
Molecular Weight:
406.22
Molecular Formula:
C13H10Cl2FN5O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diclosulam is a herbicide primarily utilized for controlling broadleaf weeds in maize and sorghum crops. It operates as a selective pre-emergence herbicide, meaning it is applied before the weeds′ germination. As an aryl urea herbicide, it belongs to the category of organic compounds acting as plant growth regulators. Its efficacy extends to the control of a wide array of weeds, including annual broadleaf weeds such as common lambsquarters, common ragweed, and common groundsel. Extensive scientific research has been dedicated to the study of Diclosulam′s properties and effects. Researchers have employed it to explore the impact of herbicides on plant growth and development, as well as the effects on soil microbial communities. Additionally, investigations have been conducted to assess its influence on weed control, environmental effects, and potential impacts on human health. Diclosulam achieves its weed-controlling effect by inhibiting the activity of acetyl-CoA carboxylase (ACCase), an enzyme in fatty acid synthesis. By hampering this enzyme′s function, the herbicide prevents the formation of long-chain fatty acids essential for plant growth and development. Consequently, the targeted weeds perish as a result of this disruption.


Diclosulam (CAS 145701-21-9) References

  1. Measurement and modeling of diclosulam runoff under the influence of simulated severe rainfall.  |  van Wesenbeeck, IJ., et al. 2001. J Environ Qual. 30: 553-60. PMID: 11285917
  2. Amaranthus palmeri resistance and differential tolerance of Amaranthus palmeri and Amaranthus hybridus to ALS-inhibitor herbicides.  |  Burgos, NR., et al. 2001. Pest Manag Sci. 57: 449-57. PMID: 11374163
  3. Terrestrial field dissipation of diclosulam at four sites in the United States.  |  Zabik, JM., et al. 2001. J Agric Food Chem. 49: 3284-90. PMID: 11453764
  4. Analysis of pesticides in soy milk combining solid-phase extraction and capillary electrophoresis-mass spectrometry.  |  Hernández-Borges, J., et al. 2005. J Sep Sci. 28: 948-56. PMID: 16013821
  5. Rapid analysis of triazolopyrimidine sulfoanilide herbicides in waters and soils by high-performance liquid chromatography with UV detection using a C18 monolithic column.  |  Rodriguez-Delgado, MA. and Hernández-Borges, J. 2007. J Sep Sci. 30: 8-14. PMID: 17313135
  6. Penoxsulam--structure-activity relationships of triazolopyrimidine sulfonamides.  |  Johnson, TC., et al. 2009. Bioorg Med Chem. 17: 4230-40. PMID: 19464188
  7. Rapid residue analysis of four triazolopyrimidine herbicides in soil, water, and wheat by ultra-performance liquid chromatography coupled to tandem mass spectrometry.  |  Liu, X., et al. 2011. Anal Bioanal Chem. 399: 2539-47. PMID: 21221546
  8. Transgenic glyphosate-resistant oilseed rape (Brassica napus) as an invasive weed in Argentina: detection, characterization, and control alternatives.  |  Pandolfo, CE., et al. 2016. Environ Sci Pollut Res Int. 23: 24081-24091. PMID: 27638808
  9. Target-site resistance to acetolactate synthase (ALS)-inhibiting herbicides in Amaranthus palmeri from Argentina.  |  Larran, AS., et al. 2017. Pest Manag Sci. 73: 2578-2584. PMID: 28703943
  10. Effect of Environmental Factors and Pesticides on Mycoparasitism of Sclerotinia minor by Coniothyrium minitans.  |  Partridge, DE., et al. 2006. Plant Dis. 90: 1407-1412. PMID: 30780907
  11. Limited Diclosulam Herbicide Uptake and Translocation-Induced Tolerance in Crotalaria juncea.  |  de Souza, CDCB., et al. 2020. Bull Environ Contam Toxicol. 104: 114-120. PMID: 31724078
  12. Remedial capacity of diclosulam by cover plants in different edaphoclimatic conditions.  |  da Silva, CT., et al. 2021. Int J Phytoremediation. 23: 609-618. PMID: 33211971
  13. Effects of cloransulam-methyl and diclosulam on soil nitrogen and carbon cycle-related microorganisms.  |  Zhang, Y., et al. 2021. J Hazard Mater. 418: 126395. PMID: 34329028
  14. A122S, A205V, D376E, W574L and S653N substitutions in acetolactate synthase (ALS) from Amaranthus palmeri show different functional impacts on herbicide resistance.  |  Palmieri, VE., et al. 2022. Pest Manag Sci. 78: 749-757. PMID: 34693637
  15. Crops with potential for diclosulam remediation and concomitant bioenergy production.  |  Silva, CT., et al. 2023. Int J Phytoremediation. 25: 275-282. PMID: 35544425

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diclosulam, 250 mg

sc-227815
250 mg
$259.00