DHRS2 Antibody (1F10): sc-517054
- DHRS2 Antibody (1F10) is a mouse monoclonal IgG2a κ DHRS2 antibody provided at 100 µg/ml
- raised against amino acids 229-300 representing partial length DHRS2 of human origin
- recommended for detection of DHRS2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DHRS2 Antibody (1F10). This work is in progress.
QUICK LINKS
DHRS2 Antibody (1F10) is a mouse monoclonal IgG2a kappa light chain antibody that detects DHRS2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-DHRS2 antibody (1F10) is available as a non-conjugated monoclonal isotype antibody. DHRS2, also known as dehydrogenase/reductase (SDR family) member 2, SDR25C1, or HEP27, consists of 258 amino acids and is primarily localized in the nucleus, where DHRS2 plays a crucial role in cellular metabolism. As an NADPH-dependent dicarbonyl reductase, DHRS2 is involved in the conversion of cortisone to cortisol, as well as the oxidation of androgens and estrogens, thereby influencing cell replication and growth. This regulatory function is particularly important in maintaining hormonal balance and cellular homeostasis, which can have significant implications in various physiological and pathological processes, including cancer and metabolic disorders. The gene encoding DHRS2 is located on human chromosome 14, a region that is home to over 700 genes and is implicated in several genetic conditions, including Alzheimer′s disease and α1-antitrypsin deficiency.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DHRS2 Antibody (1F10) References:
- Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells. | Heinz, S., et al. 2002. Genomics. 79: 608-15. PMID: 11944995
- A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product. | Pellegrini, S., et al. 2002. Biochim Biophys Acta. 1574: 215-22. PMID: 11997086
- Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue. | Shafqat, N., et al. 2006. Cell Mol Life Sci. 63: 1205-13. PMID: 16685466
- Identification of a novel nuclear protein synthesized in growth-arrested human hepatoblastoma HepG2 cells. | Donadel, G., et al. 1991. Eur J Biochem. 195: 723-9. PMID: 1847869
- The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. | Persson, B., et al. 2009. Chem Biol Interact. 178: 94-8. PMID: 19027726
- A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family. | Gabrielli, F., et al. 1995. Eur J Biochem. 232: 473-7. PMID: 7556196
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DHRS2 Antibody (1F10) | sc-517054 | 100 µg/ml | $322.00 |