DELE1 Antibody (D-11): sc-515080

DELE1 Antibody (D-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects DELE1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DELE1 (D-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DELE1 plays a crucial role in mitochondrial dynamics and is involved in the regulation of mitochondrial translation, which is essential for maintaining cellular energy homeostasis and overall cell function. Disruptions in DELE1 function can lead to mitochondrial dysfunction, contributing to various diseases, including neurodegenerative disorders and metabolic syndromes. DELE1 is located in the mitochondria, where DELE1 is vital for the synthesis of mitochondrial proteins, underscoring DELE1′s importance in cellular respiration and energy production. Understanding DELE1 function and localization can provide insights into DELE1′s role in health and disease, making anti-DELE1 antibody (D-11) an invaluable tool for researchers studying mitochondrial biology and related pathologies.

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DELE1 Antibody (D-11) References:

1. Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register.  |  Kadmon, M., et al. 2001. Int J Colorectal Dis. 16: 63-75. PMID: 11355321
2. Cockayne syndrome exhibits dysregulation of p21 and other gene products that may be independent of transcription-coupled repair.  |  Cleaver, JE., et al. 2007. Neuroscience. 145: 1300-8. PMID: 17055654
3. A new genomic mechanism leading to cri-du-chat syndrome.  |  South, ST., et al. 2006. Am J Med Genet A. 140: 2714-20. PMID: 17103439
4. Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP).  |  Aretz, S., et al. 2007. Hum Mutat. 28: 985-92. PMID: 17486639
5. Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome.  |  Du, HY., et al. 2007. Aging Cell. 6: 689-97. PMID: 17875000
6. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction.  |  Harada, T., et al. 2010. Apoptosis. 15: 1247-55. PMID: 20563667
7. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.  |  Nagase, T., et al. 1995. DNA Res. 2: 167-74, 199-210. PMID: 8590280
8. The gene for Treacher Collins syndrome maps to the long arm of chromosome 5.  |  Dixon, MJ., et al. 1991. Am J Hum Genet. 49: 17-22. PMID: 1676560
9. A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization.  |  Saltman, DL., et al. 1993. Genomics. 16: 726-32. PMID: 8325647
10. Redefining monosomy 5 by molecular cytogenetics in 23 patients with MDS/AML.  |  Herry, A., et al. 2007. Eur J Haematol. 78: 457-67. PMID: 17391336
11. Molecular mechanisms of skin aging: state of the art.  |  Makrantonaki, E. and Zouboulis, CC. 2007. Ann N Y Acad Sci. 1119: 40-50. PMID: 18056953

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DELE1 Antibody (D-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-DELE1 Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DELE1 Antibody (D-11) Specifications

Alternate Product Name: DELE1

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 338-400

Epitope Target: DELE1

Epitope Species: human

Product Reactivity/Detection: DELE1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for DELE1 Antibody (D-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin