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Deamino-histidine (CAS 1074-59-5)

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Alternate Names:
Deamino-histidine is also known as Imidazolepropionic acid.
Application:
Deamino-histidine is a histidine metabolite, potentially involved in oxidation or transamiination processes.
CAS Number:
1074-59-5
Purity:
≥98%
Molecular Weight:
140.14
Molecular Formula:
C6H8N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Deamino-histidine is a histidine metabolite, potentially involved in oxidation or transamiination processes. Deamino-histidine is an inducer of the histidine-utilization system in Salmonella typhimurium. Deamino-histidine is able to inhibit the organism′s growth on succinate minimal medium. Studies using 2,3,5-triphenyl tetrazolium chloride plates to examine amino acid catabloism have shown that accumulation of Deamino-histidine may lead to inactivation of aspartate aminio-transferase.


Deamino-histidine (CAS 1074-59-5) References

  1. Histidinemia. A deficiency in histidase resulting in the urinary excretion of histidine and of imidazolepyruvic acid.  |  AUERBACH, VH., et al. 1962. J Pediatr. 60: 487-97. PMID: 13863215
  2. Mechanism of action of urocanase. Specific 13C-labelling of the prosthetic NAD+ and revision of the structure of its adduct with imidazolylpropionate.  |  Klepp, J., et al. 1990. Eur J Biochem. 192: 669-76. PMID: 1976515
  3. Urocanate reductase: identification of a novel anaerobic respiratory pathway in Shewanella oneidensis MR-1.  |  Bogachev, AV., et al. 2012. Mol Microbiol. 86: 1452-63. PMID: 23078170
  4. Perfluorinated polymer modified vertical silicon nanowires as ultra low noise laser desorption ionization substrate for salivary metabolites profiling.  |  Jiang, X., et al. 2021. Talanta. 225: 122022. PMID: 33592752
  5. Placental metabolic profiling in gestational diabetes mellitus: An important role of fatty acids.  |  Yang, Y., et al. 2021. J Clin Lab Anal. 35: e24096. PMID: 34752662
  6. A Novel Trimethylamine Oxide-Induced Model Implicates Gut Microbiota-Related Mechanisms in Frailty.  |  Chen, SY., et al. 2022. Front Cell Infect Microbiol. 12: 803082. PMID: 35360115
  7. Gut microbiota-derived metabolites in inflammatory diseases based on targeted metabolomics.  |  Xu, H., et al. 2022. Front Pharmacol. 13: 919181. PMID: 36238574
  8. Untargeted Metabolomics Identifies Potential Hypertrophic Cardiomyopathy Biomarkers in Carriers of MYBPC3 Founder Variants.  |  Jansen, M., et al. 2023. Int J Mol Sci. 24: PMID: 36835444
  9. Inhibition of growth by imidazol(on)e propionic acid: evidence in vivo for coordination of histidine catabolism with the catabolism of other amino acids.  |  Bochner, BR. and Savageau, MA. 1979. Mol Gen Genet. 168: 87-95. PMID: 372743
  10. Genetic control of histidine degradation in Salmonella typhimurium, strain LT-2.  |  Meiss, HK., et al. 1969. J Biol Chem. 244: 5382-91. PMID: 4899017
  11. Urocanic aciduria: a defect in the urocanase activity in the liver of a mentally retarded.  |  Yoshida, T., et al. 1971. Tohoku J Exp Med. 104: 305-12. PMID: 5124677
  12. Detection by paper chromatography of imidazoles, including hydantoin-5-propionic acid, in urine after histidine dosage.  |  Middleton, JE. 1965. J Clin Pathol. 18: 605-10. PMID: 5835442
  13. Paper chromatography of some weakly basic urine constituents and the estimation of urinary tyrosine.  |  Coward, RF. and Smith, P. 1967. Clin Chim Acta. 17: 399-404. PMID: 6051635
  14. Metabolite gene regulation: imidazole and imidazole derivatives which circumvent cyclic adenosine 3',5'-monophosphate in induction of the Escherichia coli L-arabinose operon.  |  Kline, EL., et al. 1980. J Bacteriol. 141: 770-8. PMID: 6245056
  15. Choline esters and biogenic amines in the hypobranchial gland of 55 molluscan species of the neogastropod Muricoidea superfamily.  |  Roseghini, M., et al. 1996. Toxicon. 34: 33-55. PMID: 8835333

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Deamino-histidine, 250 mg

sc-294276
250 mg
$155.00

Deamino-histidine, 1 g

sc-294276A
1 g
$367.00

Deamino-histidine, 3 g

sc-294276B
3 g
$884.00

What is the optimal solution to dilute this product in?

Asked by: Marie11
Thank you for your question. This compound is soluble in water up to a concentration of 50 mg/ml.
Answered by: Tech Support Europe
Date published: 2024-03-28

Hi do you have a labeled version of DEAMINO-HISTIDINE (CAS 1074-59-5) , deuterated or otherwise labeled ?

Asked by: TonM
Thank you for your question. We currently do not offer a labeled version of this compound.
Answered by: Tech Support Europe
Date published: 2021-02-09
  • y_2026, m_4, d_23, h_7CST
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Rated 4 out of 5 by from Works goodAlthough there are some batch variations, it is working nicely in general. We also verified this chemical by mass-spec as well.
Date published: 2017-10-06
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Deamino-histidine is rated 4.0 out of 5 by 1.
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