DDX21 Antibody (F-6): sc-376573

DDX21 Antibody (F-6) is a mouse monoclonal IgG2a antibody that detects DDX21 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DDX21, also known as GUA or GURDB, is a 783 amino acid protein primarily localized in the nucleus, where DDX21 plays a crucial role in RNA metabolism and ribonucleoprotein complex assembly. DDX21 contains one helicase C-terminal domain and one helicase ATP-binding domain, enabling DDX21 to function as both a helicase that unwinds double-stranded RNA and a foldase that introduces secondary structures into single-stranded RNA. DDX21′s ability to modulate RNA structures is vital for various cellular processes, including gene expression regulation and the assembly of ribosomes and spliceosomes, which are essential for protein synthesis and mRNA processing. Notably, DDX21 is also recognized as an autoantigen in individuals suffering from watermelon stomach disease, a condition marked by chronic gastrointestinal bleeding, highlighting DDX21′s significance in both normal physiology and disease states. Anti-DDX21 antibody (F-6) is an invaluable tool for researchers investigating the intricate roles of RNA helicases in cellular function and disease mechanisms.

The preferred DDX21 antibody is DDX21 Antibody (F-5): sc-376758.