DCAKD Antibody (SQ-14): sc-100348

DCAKD Antibody (SQ-14) is a mouse monoclonal IgG1 kappa light chain antibody that detects DCAKD protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-DCAKD antibody (SQ-14) is available as a non-conjugated format. DCAKD, also known as dephospho-CoA kinase domain containing protein, is a 231 amino acid protein featuring a dephospho-CoA kinase domain and an ATP nucleotide binding motif, which are crucial for enzymatic functions. DCAKD protein primarily localizes in mitochondria and cytosol, indicating a significant role in cellular metabolism. DCAKD (SQ-14) antibody targets a member of the coaE family, suggesting involvement in coenzyme A (CoA) biosynthesis, an essential cofactor participating in various biochemical pathways, including fatty acid synthesis, oxidation, and citric acid cycle. DCAKD′s importance stems from a potential regulatory role in CoA levels, critical for energy production and metabolic homeostasis. CoA biosynthesis from pantothenic acid (vitamin B5) represents a universal process in prokaryotes and eukaryotes, with final steps performed by bifunctional enzyme COASY, whose activities remain evolutionarily conserved across species. Research into DCAKD function and regulation provides valuable insights into metabolic disorders and fundamental processes of cellular energy metabolism.

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DCAKD Antibody (SQ-14) References:

1. Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae.  |  Obmolova, G., et al. 2001. J Struct Biol. 136: 119-25. PMID: 11886213
2. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics.  |  Daugherty, M., et al. 2002. J Biol Chem. 277: 21431-9. PMID: 11923312
3. Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis.  |  Zhyvoloup, A., et al. 2002. J Biol Chem. 277: 22107-10. PMID: 11980892
4. Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase).  |  Aghajanian, S. and Worrall, DM. 2002. Biochem J. 365: 13-8. PMID: 11994049
5. Crystal structure of a trimeric form of dephosphocoenzyme A kinase from Escherichia coli.  |  O'Toole, N., et al. 2003. Protein Sci. 12: 327-36. PMID: 12538896
6. ATP-induced structural change of dephosphocoenzyme A kinase from Thermus thermophilus HB8.  |  Seto, A., et al. 2005. Proteins. 58: 235-42. PMID: 15526298
7. Dephospho-CoA kinase provides a rapid and sensitive radiochemical assay for coenzyme A and its thioesters.  |  Wadler, C. and Cronan, JE. 2007. Anal Biochem. 368: 17-23. PMID: 17603993
8. Evaluation of Parkinson disease risk variants as expression-QTLs.  |  Latourelle, JC., et al. 2012. PLoS One. 7: e46199. PMID: 23071545
9. Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging.  |  Barbu, MC., et al. 2020. Transl Psychiatry. 10: 55. PMID: 32066731
10. Investigating the Transition of Pre-Symptomatic to Symptomatic Huntington's Disease Status Based on Omics Data.  |  Christodoulou, CC., et al. 2020. Int J Mol Sci. 21: PMID: 33049985
11. An epigenome-wide DNA methylation study of patients with COVID-19.  |  Zhou, S., et al. 2021. Ann Hum Genet. 85: 221-234. PMID: 34185889
12. Mitochondrial pantetheinephosphate adenylyltransferase and dephospho-CoA kinase.  |  Skrede, S. and Halvorsen, O. 1983. Eur J Biochem. 131: 57-63. PMID: 6299733

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DCAKD Antibody (SQ-14) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DCAKD Antibody (SQ-14) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DCAKD Antibody (SQ-14) Specifications

Alternate Product Name: DCAKD

Product Clone Name: SQ-14

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 113-201

Epitope Target: DCAKD

Epitope Species: human

Product Reactivity/Detection: DCAKD

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DCAKD Antibody (SQ-14): N/A