DAZ Antibody (Z6Q): sc-100705
- DAZ Antibody (Z6Q) is a mouse monoclonal IgG1 κ DAZ antibody, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant DAZ11 of human origin
- recommended for detection of DAZ1, DAZ2, DAZ3 and DAZ4 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DAZ Antibody (Z6Q). This work is in progress.
QUICK LINKS
DAZ Antibody (Z6Q) is a mouse monoclonal IgG1 kappa light chain antibody that detects DAZ protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-DAZ antibody (Z6Q) is available as non-conjugated format. DAZ protein, which stands for "deleted in azoospermia," is crucial for spermatogenesis, where male spermatogonia develop into mature spermatozoa. DAZ proteins, including DAZ1, DAZ2, DAZ3, DAZ4, and DAZ5, are encoded by distinct genes located on Y chromosome and contain an AZFc domain in coding region. These RNA-binding proteins are primarily localized in spermatogonia nucleus, where DAZ proteins play a vital role in early stages of spermatogenesis and maintenance of germ cell populations. During meiosis, DAZ proteins translocate to cytoplasm, where DAZ proteins may influence mRNA translation through RNA recognition motif (RRM) domain, which binds to 3′ untranslated region (UTR) of target mRNAs. Deletions in genes encoding DAZ proteins can lead to conditions such as azoospermia or oligospermia, which are significant contributors to male infertility.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DAZ Antibody (Z6Q) References:
- Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1. | Tsui, S., et al. 2000. Genomics. 65: 266-73. PMID: 10857750
- Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. | Saxena, R., et al. 2000. Genomics. 67: 256-67. PMID: 10936047
- Inhibin B plasma concentrations in infertile patients with DAZ gene deletions treated with FSH. | Foresta, C., et al. 2002. Eur J Endocrinol. 146: 801-6. PMID: 12039700
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. | Skaletsky, H., et al. 2003. Nature. 423: 825-37. PMID: 12815422
- Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. | Reijo, R., et al. 1995. Nat Genet. 10: 383-93. PMID: 7670487
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DAZ Antibody (Z6Q) | sc-100705 | 100 µg/ml | $333.00 |