D2R MF: C30H25N4O11F3
MW: 674.53
A substrate for detection of intracellular caspase activation.

D2R

D2R is rated 5.0 out of 5 by 1.
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Alternate Names: (L-Asp)2 rhodamine 110 • TFA salt
Application: D2R is a substrate for detection of intracellular caspase activation
Purity: ≥98%
Molecular Weight: 674.53
Molecular Formula: C30H25N4O11F3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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D2R is a substrate for detection of intracellular caspase activation, particularly of caspase-3, after apoptosis induction in intact hematopoietic cell lines. Multiple methods of detection can be used, including fluorescence microscopy and flow cytometry.


References

1. Hug, H., et al., 1999. Rhodamine 110-linked amino acids and peptides as substrates to measure caspase activity upon apoptosis induction in intact cells. Biochemistry. 38(42): 13906-11. PMID: 10529236
2. Los, M., et al., 2000. Fluorogenic substrates as detectors of caspase activity during natural killer cell-induced apoptosis. Methods in molecular biology (Clifton, N.J.). 121(): 155-62. PMID: 10818724

Usage :
Reconstitute in DMSO followed by the addition of ethanol at a ratio 1:1, then prepare aliquots and store at -20°C, this will be stable for at least 1 month and for 6 months if storing aliquots at -80°C. Please use high purity reagents only as this dye is unstable in water; discard surplus aqueous solutions.
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Certificate of Analysis

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Rated 5 out of 5 by from D2R is a substrate utilized in the detection D2R is a substrate utilized in the detection of the intracellular activation of caspase and its use is sited in various publication. -SCBT Publication Review
Date published: 2015-07-08
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