D2R is a substrate for detection of intracellular caspase activation, particularly of caspase-3, after apoptosis induction in intact hematopoietic cell lines. Multiple methods of detection can be used, including fluorescence microscopy and flow cytometry.
1. Hug, H., et al., 1999. Rhodamine 110-linked amino acids and peptides as substrates to measure caspase activity upon apoptosis induction in intact cells. Biochemistry. 38(42): 13906-11. PMID: 10529236 2. Los, M., et al., 2000. Fluorogenic substrates as detectors of caspase activity during natural killer cell-induced apoptosis. Methods in molecular biology (Clifton, N.J.). 121(): 155-62. PMID: 10818724
Reconstitute in DMSO followed by the addition of ethanol at a ratio 1:1, then prepare aliquots and store at -20°C, this will be stable for at least 1 month and for 6 months if storing aliquots at -80°C. Please use high purity reagents only as this dye is unstable in water; discard surplus aqueous solutions.
Soluble in DMSO
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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D2R is a substrate utilized in the detectionD2R is a substrate utilized in the detection of the intracellular activation of caspase and its use is sited in various publication. -SCBT Publication Review
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