D-myo-Inositol-1,4,5-trisphosphate hexasodium salt (CAS 108340-81-4)

D-myo-Inositol-1,4,5-trisphosphate hexasodium salt, known as D-myo-Inositol-1,4,5-trisphosphate, Na6 salt or IP3, is a secondary messenger in cellular signal transduction pathways. It is extensively used in cell biology research to explore the mechanisms by which signals are propagated within cells, particularly in the context of calcium release from intracellular stores. D-myo-Inositol-1,4,5-trisphosphate hexasodium salt′s role is well-characterized in the activation of D-myo-Inositol-1,4,5-trisphosphate hexasodium salt receptors located on the membranes of the endoplasmic reticulum, which triggers the release of calcium ions into the cytoplasm, a vital step in numerous cellular processes such as muscle contraction, cell growth, and apoptosis. Researchers use D-myo-Inositol-1,4,5-trisphosphate hexasodium salt to dissect the intricacies of intracellular calcium dynamics and to understand how disruptions in calcium signaling contribute to various diseases. The sodium salt form of D-myo-Inositol-1,4,5-trisphosphate hexasodium salt improves its solubility in aqueous solutions, making it more applicable for experimental use in a range of physiological conditions. This compound is also pivotal in the study of G-protein coupled receptors (GPCRs), as it often participates in GPCR-mediated signal transduction cascades, shedding light on the complex web of cellular communications.