CSN1 Antibody (F-8): sc-377134

CSN1 Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects CSN1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CSN1, a crucial component of the COP9 signalosome complex, plays a significant role in regulating various developmental and cellular processes by mediating the deneddylation of SCF-type E3 ligase complexes, which in turn decreases the ubiquitin ligase activity of these complexes. This regulation is vital for maintaining cellular homeostasis and controlling protein degradation pathways, particularly in response to stress signals. The CSN complex, which includes other subunits such as CSN2, CSN3, and CSN5, is also involved in the phosphorylation of key proteins like p53 and c-Jun, linking CSN1 to critical cellular functions such as cell cycle regulation and apoptosis. CSN1′s ability to interact with these proteins underscores its importance in cellular signaling pathways and highlights its potential as a target for therapeutic interventions in diseases characterized by dysregulated protein degradation. Anti-CSN1 antibody (F-8) is an essential tool for researchers aiming to explore the intricate roles of the COP9 signalosome in various biological contexts.

The preferred CSN1 antibody is CSN1 Antibody (E-4): sc-514086.