CRLF1 Antibody (QQ9): sc-100297

CRLF1 Antibody (QQ9) is a mouse monoclonal IgG2a kappa light chain antibody that detects CRLF1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CRLF1 antibody (QQ9) is available as a non-conjugated monoclonal isotype antibody. CRLF1 protein, also known as cytokine receptor-like factor 1, plays a crucial role in fetal nervous system development and immune response, making CRLF1 essential for proper physiological function. This 422 amino acid secreted protein is primarily located in various tissues, including stomach, placenta, heart, ovary, thyroid, bone marrow, appendix, lymph node, spleen, thymus, and fetal lung, where CRLF1 promotes neuronal cell survival. CRLF1 interacts with cells expressing ciliary neurotrophic factor receptors, highlighting CRLF1′s importance in neuroprotection and cellular signaling pathways. Notably, defects in the gene encoding CRLF1 are associated with serious conditions such as cold-induced sweating syndrome type 1 and Crisponi syndrome, both autosomal recessive disorders that can lead to life-threatening complications. CRLF1 (QQ9) antibody is a valuable tool for researchers studying these critical biological processes and implications of CRLF1 in various diseases.

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CRLF1 Antibody (QQ9) References:

1. CNTF II, I presume?  |  Lesser, SS. and Lo, DC. 2000. Nat Neurosci. 3: 851-2. PMID: 10966608
2. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex.  |  Elson, GC., et al. 2000. Nat Neurosci. 3: 867-72. PMID: 10966616
3. Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene.  |  Knappskog, PM., et al. 2003. Am J Hum Genet. 72: 375-83. PMID: 12509788
4. Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes.  |  Dagoneau, N., et al. 2007. Am J Hum Genet. 80: 966-70. PMID: 17436251
5. Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1.  |  Crisponi, L., et al. 2007. Am J Hum Genet. 80: 971-81. PMID: 17436252
6. A null mutation in the human CNTF gene is not causally related to neurological diseases.  |  Takahashi, R., et al. 1994. Nat Genet. 7: 79-84. PMID: 8075647
7. Autosomal recessive disorder with muscle contractions resembling neonatal tetanus, characteristic face, camptodactyly, hyperthermia, and sudden death: a new syndrome?  |  Crisponi, G. 1996. Am J Med Genet. 62: 365-71. PMID: 8723066
8. Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family.  |  Elson, GC., et al. 1998. J Immunol. 161: 1371-9. PMID: 9686600

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CRLF1 Antibody (QQ9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CRLF1 Antibody (QQ9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CRLF1 Antibody (QQ9) Specifications

Alternate Product Name: CRLF1

Product Clone Name: QQ9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 135-231

Epitope Target: CRLF1

Epitope Species: human

Product Reactivity/Detection: CRLF1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CRLF1 Antibody (QQ9): N/A