CRF-BP Antibody (E-2): sc-365426

CRF-BP Antibody (E-2) is a mouse monoclonal IgG3 antibody that detects CRF-BP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CRF-BP, or corticotropin-releasing hormone-binding protein, plays a crucial role in regulating the hypothalamic-pituitary-adrenal axis by binding to corticotropin-releasing hormone (CRH) and modulating its activity. This interaction is particularly important during pregnancy, as anti-CRF-BP antibody (E-2) helps to prevent excessive stimulation of the pituitary-adrenal system, which could lead to complications. CRF-BP is primarily located in the plasma, where CRF-BP circulates and interacts with CRH, thus influencing the levels of active hormone available to exert physiological effects. The gene encoding CRF-BP is located on human chromosome 5q11.2-q13.3, and CRF-BP expression is essential for maintaining homeostasis in the stress response, especially in the context of pregnancy. CRF-BP monoclonal antibody (E-2) enables researchers to gain insights into the dynamics of stress regulation and the role of CRF-BP in various physiological and pathological conditions.

The preferred CRF-BP antibody is CRF-BP Antibody (C-8): sc-365975.