cPLA₂ Antibody (E-3): sc-137069

cPLA2 Antibody (E-3) is a mouse monoclonal IgG2a antibody that detects cytosolic phospholipase A2 (cPLA2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-cPLA2 antibody (E-3) plays a crucial role in studying lipid metabolism by detecting enzymes that hydrolyze the sn-2-acyl ester bond in glycerophospholipids, which leads to the release of free fatty acids, including arachidonic acid. This process is significant because arachidonic acid serves as a precursor for the synthesis of various eicosanoids, such as prostaglandins and leukotrienes, which are key mediators in inflammatory responses. The ability of cPLA2 to preferentially release arachidonic acid from membrane phospholipids makes cPLA2 a vital enzyme in the regulation of inflammation and cellular signaling pathways. cPLA2 is predominantly located in the cytosol of various cell types, including platelets, macrophages, and monoblasts, highlighting cPLA2′s importance in both innate and adaptive immune responses. With specificity and versatility, anti-cPLA2 antibody (E-3) is an essential tool for researchers studying the mechanisms of inflammation and lipid signaling in various biological contexts.

The preferred cPLA₂ antibody is cPLA₂ Antibody (4-4B-3C): sc-454.