CP 471474 CAS: 210755-45-6
MF: C16H16FN2O5S
MW: 368.38
A matrix metalloprotease (MMP) inhibitor.

CP 471474 (CAS 210755-45-6)

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Alternate Names: 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide; PF-1626077
Application: CP 471474 is a matrix metalloprotease (MMP) inhibitor
CAS Number: 210755-45-6
Molecular Weight: 368.38
Molecular Formula: C16H16FN2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively).


References

1. Rohde, L.E., et al. 1999. Circulation. 99: 3063-3070. PMID: 10368126
2. Lindsey, M.L., et al. 2002. Circulation. 105: 753-758. PMID: 11839633
3. Fang. L., et al. 2007. J. Mol. Cell. Cardiol. 43: 535-544. PMID: 17689559

Physical State :
Solid
Solubility :
Soluble in DMSO (≥20 mg/mL).
Storage :
Store at -20° C
Melting Point :
135-137° C (dec.)
Boiling Point :
566.97° C
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.58
IC50 :
MMP-2: IC50 = 0.7 nM (mouse); MMP-13: IC50 = 0.9 nM (mouse); MMP-9: IC50 = 13 nM (mouse); MMP-3: IC50 = 16 nM (mouse); MMP-1: IC50 = 1170 nM (mouse)
pK Values :
pKa: 9.33
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
9907286
MDL Number :
MFCD16618408
SMILES :
CC(C)(C(=O)NO)NS(=O)(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)F

Download SDS (MSDS)

Certificate of Analysis

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