Molecular structure of Compound 15e, CAS Number: 371943-05-4
Compound 15e (CAS 371943-05-4)
Application:
Compound 15e is a potent inhibitor of the PI 3-kinase p110α isoform
CAS Number:
371943-05-4
Purity:
>99%
Molecular Weight:
313.4
Molecular Formula:
C16H15N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Compound 15e is a potent and specific inhibitor of the PI 3-kinase p110α isoform. Compound 15e also inhibits proliferation of A375 melanoma cells (IC50 = 0.58 μM).
Compound 15e (CAS 371943-05-4) References
- Synthesis and antimicrobial activity of novel tetrahydrobenzothienopyrimidines. | Eissa, AA. and Moneer, AA. 2004. Arch Pharm Res. 27: 885-92. PMID: 15473655
- Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors. | Hayakawa, M., et al. 2006. Bioorg Med Chem. 14: 6847-58. PMID: 16837202
- Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of beta-1,6-glucan synthesis. | Takeshita, H., et al. 2010. Bioorg Med Chem Lett. 20: 3893-6. PMID: 20605446
- VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells. | Bekhite, MM., et al. 2011. J Cell Sci. 124: 1819-30. PMID: 21540297
- Synthesis, and docking studies of phenylpyrimidine-carboxamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors. | Zhu, W., et al. 2016. Bioorg Med Chem. 24: 1749-56. PMID: 26964675
- Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis. | Wu, X., et al. 2016. Bioorg Med Chem Lett. 26: 2284-8. PMID: 27020306
- Synthesis and bioevaluation of diarylpyrazoles as antiproliferative agents. | Wang, C., et al. 2019. Eur J Med Chem. 171: 1-10. PMID: 30901597
- A novel Apigenin derivative suppresses renal cell carcinoma via directly inhibiting wild-type and mutant MET. | Li, J., et al. 2021. Biochem Pharmacol. 190: 114620. PMID: 34043966
- Synthesis and evaluation of avermectin-imidazo[1,2-a]pyridine hybrids as potent GABAA receptor modulators. | Volkova, YA., et al. 2022. Bioorg Chem. 127: 105904. PMID: 35716646
- Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D- mannopyranosyloxy)phenyl]hexane (TBC1269). | Kogan, TP., et al. 1998. J Med Chem. 41: 1099-111. PMID: 9544210
Inhibitor of:
PI 3-kinase, PI 3-kinase C2β, PI 3-kinase p110 alpha, PI 3-kinase p110 beta, and PI 3-kinase p110 gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Compound 15e, 1 mg | sc-202551 | 1 mg | $51.00 | |||
Compound 15e, 5 mg | sc-202551A | 5 mg | $206.00 |