Molecular structure of Clopamide, CAS Number: 636-54-4
Clopamide (CAS 636-54-4)
Alternate Names:
4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-benzamide
Application:
Clopamide is a compound that selectively inhibit the sodium chloride cotransporter
CAS Number:
636-54-4
Purity:
≥98%
Molecular Weight:
345.84
Molecular Formula:
C14H20ClN3O3S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Clopamide is a diuretic compound that functions by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubule of the nephron in the kidney. This inhibition leads to increased excretion of water and electrolytes, resulting in diuresis. At the molecular level, clopamide acts by binding to the chloride-binding site of the Na+-Cl- symporter, thereby preventing the transport of sodium and chloride ions across the cell membrane. This disruption of ion transport ultimately leads to the excretion of these ions in the urine, reducing the reabsorption of water and electrolytes. In this way, clopamide plays a role in altering the balance of electrolytes, which can be relevant in certain experimental applications.
Clopamide (CAS 636-54-4) References
- In vitro and ex vivo inhibition of the modification of low-density lipoprotein by indapamide. | Breugnot, C., et al. 1992. J Cardiovasc Pharmacol. 20: 340-7. PMID: 1279277
- The effect of diuretics and vasopressin on the osmotic permeability of the frog urinary bladder. | Natochin, YV. and Shakhmatova, EI. 1976. Physiol Bohemoslov. 25: 529-34. PMID: 139627
- [ACTION OF A DIURETIC SULFONAMIDE (CLOPAMIDE) IN THE RAT DURING EXPERIMENTAL CHRONIC RENAL INSUFFICIENCY]. | BOISSIER, JR., et al. 1965. Therapie. 20: 393-9. PMID: 14326886
- Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control for diabetes mellitus. | Bukhari, SA., et al. 2014. Molecules. 19: 10129-36. PMID: 25019556
- Validated liquid chromatography-tandem mass spectrometry method for simultaneous determination of clopamide, reserpine and dihydroergotoxine: Application to pharmacokinetics in human plasma. | Sharaf El-Din, MM., et al. 2016. J Pharm Biomed Anal. 125: 236-44. PMID: 27037980
- Pharmacological properties of besulpamide, a new diuretic, in rats and dogs. | Colombo, M., et al. 1987. Methods Find Exp Clin Pharmacol. 9: 101-10. PMID: 3295429
- Inhibition of the Cl-/NaCO3- anion exchanger by xipamide in human red blood cells. | Nazaret, C., et al. 1987. Eur J Pharmacol. 144: 353-62. PMID: 3440481
- Clopamide: plasma concentrations and diuretic effect in humans. | McNeil, JJ., et al. 1987. Clin Pharmacol Ther. 42: 299-304. PMID: 3621784
- A controlled study of clopamide, clorexolone, and hydrochlorothiazide in diabetics. | Hicks, BH., et al. 1973. Metabolism. 22: 101-9. PMID: 4567002
- The influence of ethacrynic acid, hydrochlorothiazide and clopamide on the renal excretion of chloramphenicol and its metabolites. | Schück, O., et al. 1978. Int J Clin Pharmacol Biopharm. 16: 217-9. PMID: 649239
- Comparison of the effect of two groups of diuretics on renin secretion in the anaesthetized dog. | Imbs, JL., et al. 1977. Clin Sci Mol Med. 52: 171-82. PMID: 844250
- [Effect of clopamide and furosemide on blood urea in rats with congenital diabetes insipidus]. | Imbs, JL., et al. 1977. J Urol Nephrol (Paris). 83: 336-42. PMID: 894789
- Inhibition of thiazide photohemolysis in vitro by antioxidants and a nitrogen atmosphere. | Selvaag, E. 1996. Photodermatol Photoimmunol Photomed. 12: 211-5. PMID: 9112280
Inhibitor of:
NCCT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clopamide, 500 mg | sc-201553 | 500 mg | $32.00 |