claudin-11 Antibody (D-8): sc-271232

Claudin-11 Antibody (D-8) is a mouse monoclonal IgA kappa light chain antibody that detects claudin-11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-claudin-11 antibody (D-8) is available as non-conjugated format. Claudin-11 protein functions as a crucial component of tight junctions, essential for maintaining epithelial and endothelial barrier integrity. Tight junctions regulate paracellular transport, ensuring substances pass through spaces between cells in a controlled manner. Claudin-11 plays a vital role in the central nervous system, contributing to blood-brain barrier formation, a selective barrier protecting the brain from harmful substances while allowing essential nutrients to pass through. Claudin-11′s unique structure, including four transmembrane domains and two extracellular loops, facilitates tight junction strand formation that seals intercellular space. Understanding claudin-11′s function and interactions within tight junctions provides insights into various physiological processes and potential pathologies, including neurological disorders and cancer.

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claudin-11 Antibody (D-8) References:

1. Transmembrane proteins in the tight junction barrier.  |  Fanning, AS., et al. 1999. J Am Soc Nephrol. 10: 1337-45. PMID: 10361874
2. Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease.  |  Bronstein, JM., et al. 2000. J Neurosci Res. 59: 706-11. PMID: 10700007
3. Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein.  |  Fujita, K., et al. 2000. FEBS Lett. 476: 258-61. PMID: 10913624
4. Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut.  |  Rahner, C., et al. 2001. Gastroenterology. 120: 411-22. PMID: 11159882
5. The roles of claudin superfamily proteins in paracellular transport.  |  Heiskala, M., et al. 2001. Traffic. 2: 93-8. PMID: 11247307
6. Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse.  |  Wolburg, H., et al. 2001. Neurosci Lett. 307: 77-80. PMID: 11427304
7. Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions.  |  Nishiyama, R., et al. 2001. J Biol Chem. 276: 35571-80. PMID: 11466322
8. Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling.  |  Baek, JM., et al. 2018. Exp Mol Med. 50: 1-18. PMID: 29700355
9. Impaired Localization of Claudin-11 in Endometriotic Epithelial Cells Compared to Endometrial Cells.  |  Horné, F., et al. 2019. Reprod Sci. 26: 1181-1192. PMID: 30514158
10. Snail-induced claudin-11 prompts collective migration for tumour progression.  |  Li, CF., et al. 2019. Nat Cell Biol. 21: 251-262. PMID: 30664792
11. Novel Role for Claudin-11 in the Regulation of Osteoblasts via Modulation of ADAM10-Mediated Notch Signaling.  |  Lindsey, RC., et al. 2019. J Bone Miner Res. 34: 1910-1922. PMID: 31112308
12. Claudin-11 in health and disease: implications for myelin disorders, hearing, and fertility.  |  Gjervan, SC., et al. 2023. Front Cell Neurosci. 17: 1344090. PMID: 38298375

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-claudin-11 Antibody (D-8) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-claudin-11 Antibody (D-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

claudin-11 Antibody (D-8) Specifications

Alternate Product Name: claudin-11

Product Clone Name: D-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 184-207

Epitope Target: claudin-11

Epitope Species: human

Product Reactivity/Detection: claudin-11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for claudin-11 Antibody (D-8): P: Blocking Peptide