Chloroquine Antibody (6F46): sc-70856
- Chloroquine Antibody (6F46) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against Chloroquine coupled to an immunogenic carrier protein
- recommended for detection of Chloroquine by ELISA; non cross-reactive with other antimalarial drugs
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Chloroquine Antibody (6F46). This work is in progress.
QUICK LINKS
SEE ALSO...
Chloroquine Antibody (6F46) is a mouse monoclonal IgG2a antibody that detects Chloroquine in non-species reactive samples by enzyme-linked immunosorbent assay (ELISA). Chloroquine is a well-known 4-aminoquinoline compound primarily recognized for its role in the treatment and prevention of malaria, where Chloroquine exerts effects by becoming protonated within the host′s red blood cells. This protonation allows Chloroquine to bind to heme, forming the highly toxic FP-Chloroquine complex, which disrupts membrane function and leads to cell lysis, ultimately resulting in the autodigestion of the malaria parasite. Beyond antimalarial properties, Chloroquine demonstrates therapeutic potential in treating rheumatoid arthritis by inhibiting lymphocyte proliferation and modulating various immune responses, including the release of reactive oxygen species from macrophages and the production of interleukin-1. The significance of Chloroquine′s ability to diffuse into adipose tissue contributes to a high volume of distribution, which is crucial for efficacy in systemic treatments. Anti-Chloroquine antibody (6F46) serves as an essential tool for researchers studying the multifaceted roles of Chloroquine in both infectious diseases and autoimmune disorders, providing insights into mechanisms of action and potential therapeutic applications.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chloroquine Antibody (6F46) | sc-70856 | 100 µg/ml | $322.00 |