Chemokine Receptor D6 Antibody (B-12): sc-365718

Chemokine Receptor D6 Antibody (B-12) is a mouse monoclonal IgM antibody that detects Chemokine Receptor D6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Chemokine Receptor D6 antibody (B-12) is available as the non-conjugated form. Chemokine Receptor D6 protein, also known as Chemokine-binding protein 2, C-C chemokine receptor D6, CCR-9, CCR-10, and CMKBR9, is a vital member of the C-C (beta chemokine) G protein-coupled receptor family, characterized by a pair of adjacent cysteine residues. Chemokine Receptor D6 (B-12) antibody plays a crucial role in mediating the chemotaxis of T cells and phagocytic cells to sites of inflammation, contributing to immune responses and tissue repair. Chemokine Receptor D6 is primarily expressed in placental tissues and fetal liver, while also found in lymphatic endothelial cells, lymph nodes, and the mucosa of the small and large intestines. Chemokine Receptor D6 (B-12) monoclonal antibody interacts with various C-C type chemokines, including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES, and SCYA7/MCP-3, underscoring its importance in regulating immune cell trafficking and maintaining homeostasis in response to inflammatory signals.

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Chemokine Receptor D6 Antibody (B-12) References:

1. The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors.  |  Nibbs, RJ., et al. 2001. Am J Pathol. 158: 867-77. PMID: 11238036
2. The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines.  |  Weber, M., et al. 2004. Mol Biol Cell. 15: 2492-508. PMID: 15004236
3. beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.  |  Galliera, E., et al. 2004. J Biol Chem. 279: 25590-7. PMID: 15084596
4. Post-translational control of chemokines: a role for decoy receptors?  |  Comerford, I. and Nibbs, RJ. 2005. Immunol Lett. 96: 163-74. PMID: 15585320
5. The chemokine receptor D6 limits the inflammatory response in vivo.  |  Jamieson, T., et al. 2005. Nat Immunol. 6: 403-11. PMID: 15750596
6. Increased inflammation in mice deficient for the chemokine decoy receptor D6.  |  Martinez de la Torre, Y., et al. 2005. Eur J Immunol. 35: 1342-6. PMID: 15789340
7. Chemokine decoy receptor d6 plays a negative role in human breast cancer.  |  Wu, FY., et al. 2008. Mol Cancer Res. 6: 1276-88. PMID: 18708360
8. The atypical chemokine receptor D6 contributes to the development of experimental colitis.  |  Bordon, Y., et al. 2009. J Immunol. 182: 5032-40. PMID: 19342683
9. Review: Structure-function and biological properties of the atypical chemokine receptor D6.  |  Cancellieri, C., et al. 2013. Mol Immunol. 55: 87-93. PMID: 22939232
10. Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6.  |  Graham, GJ. and Locati, M. 2013. J Pathol. 229: 168-75. PMID: 23125030
11. Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.  |  Bonini, JA., et al. 1997. DNA Cell Biol. 16: 1249-56. PMID: 9364936
12. Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.  |  Nibbs, RJ., et al. 1997. J Biol Chem. 272: 32078-83. PMID: 9405404

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Chemokine Receptor D6 Antibody (B-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Chemokine Receptor D6 Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Chemokine Receptor D6 Antibody (B-12) Specifications

Alternate Product Name: Chemokine Receptor D6

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 361-391

Epitope Target: Chemokine Receptor D6

Epitope Species: human

Product Reactivity/Detection: Chemokine Receptor D6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Chemokine Receptor D6 Antibody (B-12): P: Blocking Peptide