Molecular structure of CFM 1571 hydrochloride, CAS Number: 1215548-30-3
CFM 1571 hydrochloride (CAS 1215548-30-3)
CAS Number:
1215548-30-3
Molecular Weight:
444.95
Molecular Formula:
C23H28N4O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CFM 1571 hydrochloride is soluble guanylyl cyclase (sGC) activator (EC50 = 5.49 μM). Does not activate adenylyl cyclase, shows no significant inhibition of phosphodiesterases and displays minimal inhibition of iNOS (25%) and nNOS (17%). CFM 1571 hydrochloride inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM).
CFM 1571 hydrochloride (CAS 1215548-30-3) References
- Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. | Selwood, DL., et al. 2001. J Med Chem. 44: 78-93. PMID: 11141091
- NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. | Evgenov, OV., et al. 2006. Nat Rev Drug Discov. 5: 755-68. PMID: 16955067
- Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. | Kotzki, S., et al. 2013. J Pharmacol Exp Ther. 346: 424-31. PMID: 23838678
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CFM 1571 hydrochloride, 10 mg | sc-203540 | 10 mg | $250.00 | |||
CFM 1571 hydrochloride, 50 mg | sc-203540A | 50 mg | $1400.00 | |||
CFM 1571 hydrochloride, 100 mg | sc-203540B | 100 mg | $2570.00 |