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Cefpiramide (CAS 70797-11-4)

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Application:
Cefpiramide is β-lactam antibiotic
CAS Number:
70797-11-4
Molecular Weight:
612.64
Molecular Formula:
C25H24N8O7S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cefpiramide is a cephalosporin antibiotic demonstrating a broad spectrum of activity against both Gram-positive and Gram-negative bacteria. Classified as a third-generation cephalosporin, it shares a chemical relation to cefotaxime and ceftriaxone. In the realm of scientific research, cefpiramide has undergone extensive investigation. It has played a role in exploring the mechanisms of action associated with cephalosporin antibiotics, shedding light on their intricate workings. The mechanism of action of cefpiramide arises from its ability to inhibit the synthesis of the bacterial cell wall. By binding to penicillin-binding proteins, enzymes responsible for cell wall synthesis, cefpiramide impedes their function. Consequently, the formation of the cell wall is hindered, leading to the demise of the bacterial cells.


Cefpiramide (CAS 70797-11-4) References

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  2. Protein binding of cefpiramide in the plasma of various species.  |  Ohshima, T., et al. 1991. J Pharm Pharmacol. 43: 805-6. PMID: 1686912
  3. Membrane potential-dependent and carrier-mediated transport of cefpiramide, a cephalosporin antibiotic, in canalicular rat liver plasma membrane vesicles.  |  Tamai, I., et al. 1990. J Pharmacol Exp Ther. 253: 537-44. PMID: 2338647
  4. Application of a trap-free two-dimensional liquid chromatography combined with ion trap/time-of-flight mass spectrometry for separation and characterization of impurities and isomers in cefpiramide.  |  Wang, J., et al. 2017. Anal Chim Acta. 992: 42-54. PMID: 29054149
  5. Uptake of benzylpenicillin, cefpiramide and cefazolin by freshly prepared rat hepatocytes. Evidence for a carrier-mediated transport system.  |  Tsuji, A., et al. 1986. Biochem Pharmacol. 35: 151-8. PMID: 3080003
  6. Quantitation of plasma and biliary cefpiramide concentrations in human samples using high-performance liquid chromatography.  |  Yoon, J., et al. 2020. Biomed Chromatogr. 34: e4957. PMID: 32706918
  7. Renal tubular mechanisms for excretion of cefpiramide (SM-1652) in association with its long-lasting pharmacokinetic properties.  |  Matsui, H. and Okuda, T. 1988. J Pharmacobiodyn. 11: 67-73. PMID: 3379566
  8. Therapeutic efficacy of cefpiramide and cefoperazone alone and in combination with gentamicin against pseudomonal infections in neutropenic mice.  |  Fu, KP., et al. 1986. Chemotherapy. 32: 166-72. PMID: 3698725
  9. Cefpiramide: comparative in-vitro activity and beta-lactamase stability.  |  Barry, AL., et al. 1985. J Antimicrob Chemother. 16: 315-25. PMID: 3877041
  10. Comparative in vitro activities of cefpiramide and apalcillin individually and in combination.  |  Allan, JD., et al. 1985. Antimicrob Agents Chemother. 27: 782-90. PMID: 3925875
  11. Biliary cefpiramide excretion: its relation to biliary excretion of bile acids and sulfobromophthalein.  |  Takikawa, H., et al. 1995. Pharmacology. 51: 24-32. PMID: 7568341
  12. Glutathione S-transferases as a cefpiramide binding protein in rat liver.  |  Guji, A., et al. 1995. Pharmacol Toxicol. 76: 212-7. PMID: 7617548
  13. Cefpiramide kinetics and plasma protein binding in cholestasis.  |  Demontes-Mainard, F., et al. 1994. Br J Clin Pharmacol. 37: 295-7. PMID: 8198940

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cefpiramide, 10 mg

sc-278822
10 mg
$182.00