Cdc123 Antibody (G-10): sc-365596

Cdc123 Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects Cdc123 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cdc123, also known as cell division cycle protein 123 or D123, is a crucial 336 amino acid cytoplasmic protein that plays a significant role in regulating the cell cycle. Cdc123 is predominantly expressed in tissues such as the thymus, spleen, ovary, testis, small intestine, and leukocytes, highlighting its importance in various biological processes. The primary function of Cdc123 is to destabilize checkpoint with forkhead and ring finger domain (Chfr) proteins, which, if allowed to accumulate, can inhibit the transition from the G1 to S phase of the cell cycle. By preventing the buildup of Chfr proteins, Cdc123 facilitates the progression of cells into the S phase, thereby promoting normal cell division. This regulatory mechanism is particularly important in the context of cancer, as Cdc123 is considered a basal marker for luminal breast cancers, making Cdc123 a valuable target for research and therapeutic applications. Anti-Cdc123 antibody (G-10) is an essential tool for scientists studying cell cycle dynamics and the molecular underpinnings of cancer.

The preferred Cdc123 antibody is Cdc123 Antibody (A-2): sc-390989.