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CD74 Antibody (In-1) - Flow Cytometry - Image 17868
CD74 抗体 (In-1) FITC: sc-19627. 用 CD74 抗体 (In-1) FITC 染色的 C57BL/6 小鼠脾脏的间接/直接 FCM 分析 (绿色直方图). 黑线直方图代表同型对照大鼠 IgG2b: sc-2835.
CD74 抗体 (In-1) FITC: sc-19627. 用 CD74 抗体 (In-1) FITC 染色的 C57BL/6 小鼠脾脏的间接/直接 FCM 分析 (绿色直方图). 黑线直方图代表同型对照大鼠 IgG2b: sc-2835.

CD74 抗体 (In-1): sc-19627

4.3(8)
寫評論提問
说明书
  • CD74 抗体 In-1 是大鼠单克隆 IgG2b, 在1篇文献中引用，提供 200 µg/ml
  • 推荐用于 mouse 来源的CD74 WB, IP, IF 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 看 CD74 (LN-2): sc-6262，可查看有标记的 CD74 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成CD74 抗体 (In-1)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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此外 CD74 抗体包括 CD74L

人类组织相容性白细胞抗原（HLA）类II相关不变链由至少四个多肽组成。其中一条多肽链表达为膜结合的亚基，被称为CD74。类II MHC蛋白（MHC II）上肽的装载似乎受到CD74的调节，它在MHC II迁移到内吞体小室（endosomal compartment）时与MHC II相关联，在该小室中，类II结合肽。CD74由T淋巴细胞和B淋巴细胞系的细胞表达。事实上，CD74在正常的B淋巴细胞中广泛表达，而不论它们的组织相容性白细胞抗原（HLA）表型如何，而外周T淋巴细胞的一个子集，即MHC II阴性细胞不表达CD74。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD74 抗体 (In-1) 参考文献:

  1. 肺腺癌中的 CD74-NRG1 融合。  |  Fernandez-Cuesta, L., et al. 2014. Cancer Discov. 4: 415-22. PMID: 24469108
  2. CD74 消融可通过诱发的铁蛋白沉积调节挽救 2 型糖尿病诱发的心脏重塑和收缩功能障碍。  |  Chen, L., et al. 2022. Pharmacol Res. 176: 106086. PMID: 35033649
  3. CD74-NRG1 融合在体内具有致癌作用，并诱导可治疗的 ERBB2:ERBB3 异源二聚化  |  Werr, L., et al. 2022. Mol Cancer Ther. 21: 821-830. PMID: 35247925
  4. 感染和炎症刺激CD74+潘氏细胞亚群的扩张，以调节疾病进展。  |  Balasubramanian, I., et al. 2023. EMBO J. 42: e113975. PMID: 37718683
  5. CD74缺陷可减少子痫前期中由SIRT1介导的滋养层细胞侵袭和增殖。  |  Liu, Z., et al. 2023. Reproduction. 166: 423-435. PMID: 37796743
  6. 与TP53突变无关的CD74/SLC34A2-ROS1跨膜区融合变异可预测NSCLC患者对克唑替尼的不良反应。  |  Li, W., et al. 2024. J Thorac Oncol. 19: 613-625. PMID: 38070598
  7. CD74在常染色体显性多囊肾中促进囊肿生长和肾纤维化。  |  Zhou, JX., et al. 2024. Cells. 13: PMID: 38534333
  8. CD74 是活化的 CD4+ T 细胞上的功能性 MIF 受体  |  Zhang, L., et al. 2024. Cell Mol Life Sci. 81: 296. PMID: 38992165
  9. 靶向肿瘤相关巨噬细胞衍生的CD74可提高新辅助化疗联合PD-1阻断治疗宫颈癌的疗效。  |  Wang, Z., et al. 2024. J Immunother Cancer. 12: PMID: 39107132
  10. CD74通过塑造肝癌的肿瘤微环境促进免疫治疗反应。  |  Cheng, J., et al. 2024. Mol Med. 30: 116. PMID: 39118044

订购信息

产品名称产品编号规格价格数量收藏夹

CD74 抗体 (In-1)

sc-19627
200 µg/ml
$322.00

CD74 抗体 (In-1) FITC

sc-19627 FITC
200 µg/ml
$336.00

CD74 抗体 (In-1) PE

sc-19627 PE
200 µg/ml
$349.00

Can CD74 (In-1): sc-19627 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Cweed
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CD74 (In-1): sc-19627 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by ruixinde99 from Good quality for WBAlthrough the antibody dilution suggest from 1:200 to 1:1000,the range is wide.However,the optimal staining conditions can easily be established.finally ,I choose 1:500 dilution for mouse brain tissue detection.
Date published: 2017-07-15
Rated 5 out of 5 by shafan from Clear band seenClear band seen use this antibody.Also the result is very satisfied us, it give us the right expression level of the controled group and Treatment group(a little blot background).
Date published: 2017-07-08
Rated 5 out of 5 by AbPolly from Good FCM CloneThe FITC conjugated version of this antibody performs well in Flow Cytometry, shows good separation from the normal control.
Date published: 2017-01-27
Rated 4 out of 5 by CZ from Nice results in FlowNice results in Flow.
Date published: 2015-10-08
Rated 3 out of 5 by JM from Acceptable FCM data of mouse peripheral bloodAcceptable FCM data of mouse peripheral blood leukocytes. -SCBT QC
Date published: 2015-06-01
Rated 4 out of 5 by SS from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2015-05-24
Rated 3 out of 5 by LR from Produced nice indirect/Direct FCM data forProduced nice indirect/Direct FCM data for mouse spleen. -SCBT QC
Date published: 2013-07-29
Rated 5 out of 5 by Anke from works greatworks great
Date published: 2003-06-26
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CD74抗体 (In-1) is rated 4.3 out of 5 by 8.
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