CD43 Antibody (MT1): sc-51727

CD43 Antibody (MT1) is a mouse monoclonal IgG1 antibody that detects CD43 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). CD43, also known as leukosialin, is a major O-glycosylated sialoglycoprotein predominantly found on the surface of leukocytes, where CD43 plays a crucial role in cellular adhesion and immune response regulation. CD43 is a member of the surface mucin family and is involved in the modulation of cell-cell interactions, which is vital for maintaining proper immune function and preventing excessive inflammation. Notably, CD43 is recognized as a negative regulator of cellular adhesion, which means CD43 can inhibit the binding of leukocytes to other cells and extracellular matrix components, thereby influencing processes such as tumor progression and metastasis. The ability of CD43 to modulate adhesion is particularly important in the context of T cell activation and migration, making CD43 a valuable marker for identifying both normal and neoplastic T cells, as well as a subset of neoplastic B cells within various tissues. Anti-CD43 antibody (MT1) is an essential tool for researchers studying immune responses, cancer biology, and cellular interactions.

The preferred CD43 antibody is CD43 Antibody (DF-T1): sc-6256.