CD209e Antibody (LL19): sc-73801

CD209e Antibody (LL19) is a rat monoclonal IgG2b antibody that detects CD209e protein of mouse origin by western blotting (WB). Anti-CD209e antibody (LL19) is available as a non-conjugated format, specifically designed to facilitate the study of antigen-presenting cells, which play a crucial role in the immune response. CD209e protein is primarily located on the surface of dendritic cells, where CD209e (LL19) monoclonal antibody is essential for mediating the endocytosis of pathogens and their subsequent degradation within lysosomal compartments. This localization allows dendritic cells to capture antigens or viruses in peripheral tissues and transport them to lymphoid organs, thereby inducing cellular T cell responses that are critical for effective immunity. The mouse CD209 family includes several members, such as CD209a (DC-SIGN), CD209b, CD209c, CD209d, CD209e, CD209f, and CD209g, all of which contribute to the immune system′s ability to recognize and respond to pathogens. Understanding CD209e function and location is important for developing therapeutic strategies aimed at enhancing immune responses or targeting specific pathways in disease contexts.

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CD209e Antibody (LL19) References:

1. The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells.  |  Engering, A., et al. 2002. J Immunol. 168: 2118-26. PMID: 11859097
2. Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo.  |  Geijtenbeek, TB., et al. 2002. Blood. 100: 2908-16. PMID: 12351402
3. DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation.  |  Moris, A., et al. 2004. Blood. 103: 2648-54. PMID: 14576049
4. L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus.  |  Cormier, EG., et al. 2004. Proc Natl Acad Sci U S A. 101: 14067-72. PMID: 15371595
5. Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN.  |  Weber, KS., et al. 2004. Inflammation. 28: 177-88. PMID: 15673159
6. Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction.  |  Groot, F., et al. 2005. J Virol. 79: 3009-15. PMID: 15709021
7. Regulated recruitment of DC-SIGN to cell-cell contact regions during zymosan-induced human dendritic cell aggregation.  |  de la Rosa, G., et al. 2005. J Leukoc Biol. 77: 699-709. PMID: 15728245
8. A variant in the CD209 promoter is associated with severity of dengue disease.  |  Sakuntabhai, A., et al. 2005. Nat Genet. 37: 507-13. PMID: 15838506
9. The location of asparagine-linked glycans on West Nile virions controls their interactions with CD209 (dendritic cell-specific ICAM-3 grabbing nonintegrin).  |  Davis, CW., et al. 2006. J Biol Chem. 281: 37183-94. PMID: 17001080