CD1E Antibody (CC118): sc-101833
- CD1E Antibody (CC118) is a mouse monoclonal IgG1 κ CD1E antibody provided at 200 µg/ml
- raised against thymocytes of bovine origin
- CD1E Antibody (CC118) is recommended for detection of CD1E of bovine, ovine and caprine origin by WB, IP and FCM
- Anti-CD1E Antibody (CC118) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD1E Antibody (CC118) for WB applications. These reagents are now offered in bundles with CD1E Antibody (CC118) (see ordering information below).
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CD1E Antibody (CC118) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD1E protein of bovine, ovine, and caprine origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-CD1E antibody (CC118) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD1E, also known as R2 or CD1A, is a 322 amino acid single-pass type I membrane protein that plays a crucial role in the immune system by mediating the presentation of lipid antigens derived from microbial or self-origin on the surface of immune cells. CD1E is primarily localized in the lumen of the endoplasmic reticulum and the Golgi apparatus, where CD1E associates with β-2-Microglobulin to form a heterodimer essential for glycolipid antigen presentation. CD1E is expressed in various tissues, including cortical thymocytes, dendritic cells, and Langerhans cells, highlighting CD1E′s importance in immune responses. CD1E undergoes post-translational modifications, including mono-ubiquitination, which can influence stability and function, and CD1E may also be proteolytically cleaved in endosomes to produce a soluble form. CD1E presence on the surface of certain T-cell leukemias suggests a potential involvement in tumorigenesis, making CD1E a significant target for research in immunology and cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD1E Antibody (CC118) References:
- Polymorphism of human CD1 genes. | Han, M., et al. 1999. Tissue Antigens. 54: 122-7. PMID: 10488738
- Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. | Angenieux, C., et al. 2000. J Biol Chem. 275: 37757-64. PMID: 10948205
- Identification of two novel human CD1E alleles. | Mirones, I., et al. 2000. Tissue Antigens. 56: 159-61. PMID: 11019917
- Common characteristics of the human and rhesus macaque CD1e molecules: conservation of biochemical and biological properties during primate evolution. | Angénieux, C., et al. 2003. Immunogenetics. 54: 842-9. PMID: 12671734
- Control of the intracellular pathway of CD1e. | Maître, B., et al. 2008. Traffic. 9: 431-45. PMID: 18208508
- Two classes of CD1 genes. | Calabi, F., et al. 1989. Eur J Immunol. 19: 285-92. PMID: 2467814
- A physical map linking the five CD1 human thymocyte differentiation antigen genes. | Yu, CY. and Milstein, C. 1989. EMBO J. 8: 3727-32. PMID: 2583117
- Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. | Martin, LH., et al. 1986. Proc Natl Acad Sci U S A. 83: 9154-8. PMID: 3097645
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD1E Antibody (CC118) | sc-101833 | 200 µg/ml | $322.00 | |||
CD1E Antibody (CC118): m-IgG Fc BP-HRP Bundle | sc-527073 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD1E Antibody (CC118): m-IgG1 BP-HRP Bundle | sc-532446 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD1E Antibody (CC118) AC | sc-101833 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD1E Antibody (CC118) HRP | sc-101833 HRP | 200 µg/ml | $322.00 | |||
CD1E Antibody (CC118) FITC | sc-101833 FITC | 200 µg/ml | $336.00 | |||
CD1E Antibody (CC118) PE | sc-101833 PE | 200 µg/ml | $349.00 | |||
CD1E Antibody (CC118) Alexa Fluor® 488 | sc-101833 AF488 | 200 µg/ml | $364.00 | |||
CD1E Antibody (CC118) Alexa Fluor® 546 | sc-101833 AF546 | 200 µg/ml | $364.00 | |||
CD1E Antibody (CC118) Alexa Fluor® 594 | sc-101833 AF594 | 200 µg/ml | $364.00 | |||
CD1E Antibody (CC118) Alexa Fluor® 647 | sc-101833 AF647 | 200 µg/ml | $364.00 | |||
CD1E Antibody (CC118) Alexa Fluor® 680 | sc-101833 AF680 | 200 µg/ml | $364.00 | |||
CD1E Antibody (CC118) Alexa Fluor® 790 | sc-101833 AF790 | 200 µg/ml | $364.00 |