CCDC91 Antibody (D-12): sc-514452
- CCDC91 Antibody (D-12) is a mouse monoclonal IgG2a κ CCDC91 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 91-110 within an internal region of CCDC91 of human origin
- CCDC91 Antibody (D-12) is recommended for detection of CCDC91 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CCDC91 Antibody (D-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CCDC91 Antibody (D-12) for WB applications. These reagents are now offered in bundles with CCDC91 Antibody (D-12) (see ordering information below).
CCDC91 Antibody (D-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects CCDC91 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-CCDC91 antibody (D-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CCDC91, also known as coiled-coil domain-containing protein 91 or GGABP (GGA-binding partner), is a critical 441 amino acid membrane protein that plays a vital role in regulating membrane traffic through the trans-Golgi network (TGN). CCDC91 exists as three alternatively spliced isoforms and forms a homodimer, which is essential for function. CCDC91 interacts with key proteins such as GGA1, GGA2, and γ1-Adaptin, facilitating the sorting and transport of proteins within the cell. The gene encoding CCDC91 is located on human chromosome 12p11.22, spanning approximately 446,702 bases and containing over 1,100 genes. Chromosome 12 is significant not only for encoding crucial transcription factors involved in morphogenesis but also for association with various skeletal deformities and developmental syndromes, including Noonan syndrome. Proper functioning of CCDC91 is essential for maintaining cellular homeostasis and ensuring efficient intracellular transport, making CCDC91 a valuable target for research in cell biology and related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCDC91 Antibody (D-12) References:
- [Achondrogenesis type II-hypochondrogenesis: radiological features.Case report]. | Delgado Carrasco, J., et al. 2001. An Esp Pediatr. 55: 553-7. PMID: 11730591
- Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. | Lui, WW., et al. 2003. Mol Biol Cell. 14: 2385-98. PMID: 12808037
- Structural basis for binding of accessory proteins by the appendage domain of GGAs. | Collins, BM., et al. 2003. Nat Struct Biol. 10: 607-13. PMID: 12858163
- A case of Kniest dysplasia with retinal detachment and the mutation analysis. | Yokoyama, T., et al. 2003. Am J Ophthalmol. 136: 1186-8. PMID: 14644246
- The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting. | Mardones, GA., et al. 2007. Mol Biol Cell. 18: 3486-501. PMID: 17596511
- A familial case of achondrogenesis type II caused by a dominant COL2A1 mutation and 'patchy' expression in the mosaic father. | Forzano, F., et al. 2007. Am J Med Genet A. 143A: 2815-20. PMID: 17994563
- Visceral manifestations of hypochondrogenesis. | Wainwright, H. and Beighton, P. 2008. Virchows Arch. 453: 203-7. PMID: 18642028
- Trisomy 12p and monosomy 4p: phenotype-genotype correlation. | Benussi, DG., et al. 2009. Genet Test Mol Biomarkers. 13: 199-204. PMID: 19378504
- High resolution melting analysis for mutation detection for PTPN11 gene: applications of this method for diagnosis of Noonan syndrome. | Lo, FS., et al. 2009. Clin Chim Acta. 409: 75-7. PMID: 19737548
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCDC91 Antibody (D-12) | sc-514452 | 200 µg/ml | $316.00 | |||
CCDC91 Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-531132 | 200 µg Ab; 10 µg BP | $354.00 | |||
CCDC91 Antibody (D-12): m-IgGκ BP-HRP Bundle | sc-524732 | 200 µg Ab, 40 µg BP | $354.00 | |||
CCDC91 Antibody (D-12): m-IgG2a BP-HRP Bundle | sc-547698 | 200 µg Ab; 10 µg BP | $354.00 | |||
CCDC91 Antibody (D-12) AC | sc-514452 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CCDC91 Antibody (D-12) HRP | sc-514452 HRP | 200 µg/ml | $316.00 | |||
CCDC91 Antibody (D-12) FITC | sc-514452 FITC | 200 µg/ml | $330.00 | |||
CCDC91 Antibody (D-12) PE | sc-514452 PE | 200 µg/ml | $343.00 | |||
CCDC91 Antibody (D-12) Alexa Fluor® 488 | sc-514452 AF488 | 200 µg/ml | $357.00 | |||
CCDC91 Antibody (D-12) Alexa Fluor® 546 | sc-514452 AF546 | 200 µg/ml | $357.00 | |||
CCDC91 Antibody (D-12) Alexa Fluor® 594 | sc-514452 AF594 | 200 µg/ml | $357.00 | |||
CCDC91 Antibody (D-12) Alexa Fluor® 647 | sc-514452 AF647 | 200 µg/ml | $357.00 | |||
CCDC91 Antibody (D-12) Alexa Fluor® 680 | sc-514452 AF680 | 200 µg/ml | $357.00 | |||
CCDC91 Antibody (D-12) Alexa Fluor® 790 | sc-514452 AF790 | 200 µg/ml | $357.00 | |||
CCDC91 (D-12) Neutralizing Peptide | sc-514452 P | 100 µg/0.5 ml | $68.00 |