Molecular structure of CB 1954, CAS Number: 21919-05-1
CB 1954 (CAS 21919-05-1)
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Alternate Names:
5-(1-Aziridinyl)-2,4-dinitrobenzamide
Application:
CB 1954 is a compound for gene therapy resrearch
CAS Number:
21919-05-1
Purity:
>97%
Molecular Weight:
252.18
Molecular Formula:
C9H8N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CB 1954 is thought to work by hindering the activity of topoisomerase II, an enzyme. It also suppresses the production of specific cytokines that promote inflammation and blood vessel formation. Additionally, CB 1954 has demonstrated the ability to trigger programmed cell death in cancer cells and impede the formation of new blood vessels, for the proliferation and metastasis of cancer cells.
CB 1954 (CAS 21919-05-1) References
- Phthalimide analogs of CB 1954: synthesis and bioactivation. | Mehta, LK., et al. 1999. Anticancer Drugs. 10: 777-83. PMID: 10573210
- Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs. | Miŝkiniene, V., et al. 1999. Cancer Lett. 146: 217-22. PMID: 10656629
- Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954. | Anlezark, GM., et al. 2002. Microbiology (Reading). 148: 297-306. PMID: 11782522
- Aerobic nitroreduction by flavoproteins: enzyme structure, mechanisms and role in cancer chemotherapy. | Skelly, JV., et al. 2001. Mini Rev Med Chem. 1: 293-306. PMID: 12369976
- Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation. | Helsby, NA., et al. 2003. Chem Res Toxicol. 16: 469-78. PMID: 12703963
- Development of novel selective cell ablation in the mammary gland and brain to study cell-cell interactions and chemoprevention. | Gusterson, BA., et al. 2003. Recent Results Cancer Res. 163: 31-45; discussion 264-6. PMID: 12903841
- CB 1954: from the Walker tumor to NQO2 and VDEPT. | Knox, RJ., et al. 2003. Curr Pharm Des. 9: 2091-104. PMID: 14529407
- 2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT. | Helsby, NA., et al. 2004. Br J Cancer. 90: 1084-92. PMID: 14997211
- Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase. | Helsby, NA., et al. 2004. J Med Chem. 47: 3295-307. PMID: 15163209
- New enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution. | Barak, Y., et al. 2006. Mol Cancer Ther. 5: 97-103. PMID: 16432167
- Validation of nitroreductase, a prodrug-activating enzyme, mediated cell death in embryonic zebrafish (Danio rerio). | Pisharath, H. 2007. Comp Med. 57: 241-6. PMID: 17605338
- Hepatic nitroreduction, toxicity and toxicokinetics of the anti-tumour prodrug CB 1954 in mouse and rat. | Tang, MH., et al. 2007. Toxicology. 240: 70-85. PMID: 17804142
- The synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1-a]isoquinoline N-oxides and related heterocycles as potential bioreducible substrates for the enzymes NAD(P)H: quinone oxidoreductase 1 and E. coli nitroreductase. | Burke, PJ., et al. 2011. Bioorg Med Chem Lett. 21: 7447-50. PMID: 22074961
- Combinatorial Effects of Thymoquinone on the Anticancer Activity and Hepatotoxicity of the Prodrug CB 1954. | Talib, WH. and Abukhader, MM. 2013. Sci Pharm. 81: 519-30. PMID: 23833717
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Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CB 1954, 50 mg | sc-214672 | 50 mg | $224.00 | |||
CB 1954, 100 mg | sc-214672A | 100 mg | $444.00 | |||
CB 1954, 1 g | sc-214672B | 1 g | $4301.00 | |||
CB 1954, 5 g | sc-214672C | 5 g | $13775.00 | |||
CB 1954, 10 g | sc-214672D | 10 g | $24485.00 |