Molecular structure of CB 13, CAS Number: 432047-72-8
CB 13 (CAS 432047-72-8)
Alternate Names:
1-naphthalenyl[4-(pentylox)-1-naphthalenyl]-methanone; CRA-13
Application:
CB 13 is a potent CB1/CB2 receptor agonist with limited brain penetration
CAS Number:
432047-72-8
Purity:
>98%
Molecular Weight:
368.47
Molecular Formula:
C26H24O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Potent, orally active CB1/CB2 receptor agonist with limited brain penetration (EC50 values are 6.1 and 27.9 nM for CB1 and CB2 receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.
CB 13 (CAS 432047-72-8) References
- URB-754: a new class of designer drug and 12 synthetic cannabinoids detected in illegal products. | Uchiyama, N., et al. 2013. Forensic Sci Int. 227: 21-32. PMID: 23063179
- Ligand activation of cannabinoid receptors attenuates hypertrophy of neonatal rat cardiomyocytes. | Lu, Y., et al. 2014. J Cardiovasc Pharmacol. 64: 420-30. PMID: 24979612
- Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors. | Fichna, J., et al. 2014. PLoS One. 9: e109115. PMID: 25275313
- Cannabinoid signaling in health and disease. | Lu, Y. and Anderson, HD. 2017. Can J Physiol Pharmacol. 95: 311-327. PMID: 28263083
- Activation of Cannabinoid Receptors Attenuates Endothelin-1-Induced Mitochondrial Dysfunction in Rat Ventricular Myocytes. | Lu, Y., et al. 2020. J Cardiovasc Pharmacol. 75: 54-63. PMID: 31815823
- Cannabinoid1 (CB-1) receptor antagonists: a molecular approach to treating acute cannabinoid overdose. | Skolnick, P. and Crystal, R. 2020. J Neural Transm (Vienna). 127: 279-286. PMID: 31893308
- Synthetic cannabinoid receptor agonists: Analytical profiles and development of QMPSB, QMMSB, QMPCB, 2F-QMPSB, QMiPSB, and SGT-233. | Brandt, SD., et al. 2021. Drug Test Anal. 13: 175-196. PMID: 32880103
- Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival. | Tang, X., et al. 2021. Int J Mol Sci. 22: PMID: 34206926
- Role of primary sensory neurone cannabinoid type-1 receptors in pain and the analgesic effects of the peripherally acting agonist CB-13 in mice. | Ford, NC., et al. 2022. Br J Anaesth. 128: 159-173. PMID: 34844727
- The cannabinoid agonist CB-13 produces peripherally mediated analgesia in mice but elicits tolerance and signs of central nervous system activity with repeated dosing. | Slivicki, RA., et al. 2022. Pain. 163: 1603-1621. PMID: 34961756
Activator of:
CB1, and CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CB 13, 10 mg | sc-203870 | 10 mg | $115.00 | |||
CB 13, 50 mg | sc-203870A | 50 mg | $473.00 |