CAY10571 (CAS 152121-46-5)
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Pyridinylimidazoles, often called CSAIDs, are a class of anti-inflammatory compounds that suppress the synthesis of cytokines in human monocytes and inhibit eicosanoid productio (1). Because of its high specificity, one predominant pyridinylimidazole, SB203580, is frequently used to inhibit p38 MAPK, the tyrosine kinase activated by inflammatory cytokines and environmental stresses (2). CAY10571 is an analog of SB203580 that inhibits IL-1 production in the human monocytic cell line THP (1) with an IC50 value of 0.20 µM and binds CSAID binding protein, a serine/threonine kinase homologous to p38, inhibiting its kinase activity with an IC50 value of 0.03 µM (3,4). This chemical also inhibits 5-lipoxygenase production in RBL-1 cells with an IC50 value of 24 µM (3).
CAY10571 (CAS 152121-46-5) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAY10571, 5 mg | sc-223869 | 5 mg | $56.00 | |||
CAY10571, 10 mg | sc-223869A | 10 mg | $140.00 |