CAY10571 CAS: 152121-46-5
MF: C21H16FN3O2S
MW: 393.43
A cell permeable, reversible, and ATP-competitive sulfone analog of the p38 MAP kinase inhibitor.

CAY10571 (CAS 152121-46-5)

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Synonym: SB 203580, Sulfone; 4-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole
Application: A cell permeable, reversible, and ATP-competitive sulfone analog of the p38 MAP kinase inhibitor
CAS Number: 152121-46-5
Molecular Weight: 393.43
Molecular Formula: C21H16FN3O2S
* Refer to Certificate of Analysis for lot specific data (including water content).

CAY10571 is a cell permeable, reversible, and ATP-competitive sulfone analog of the p38 MAP kinase inhibitor SB 203580. Potently inhibits p38 kinase (IC50 = 30 nM) and inhibits IL-1 production in human monocytes (IC50 = 200 nM).


References

1. Lee, J.C., et al. 1994. Nature 372: 739-746. PMID: 7997261
2. Cuenda, A., et al. 1995. FEBS Lett. 364: 229-233. PMID: 7750577
3. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5: 49-64. PMID: 9043657

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml), DMF (~50 mg/ml), and 1:3 DMF:PBS (pH 7.2) (~0.25 mg/ml).
Storage :
Store at -20° C
Melting Point :
284.55° C (Predicted)
Boiling Point :
~635.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
p38K: IC50 = 30 nM; IL-1 production: IC50 = 200 nM (human); 5-lipoxygenase production: IC50 = 24 µM (RBL-1 cells)
pK Values :
pKb: 9.16 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6610350
MDL Number :
MFCD00922197
SMILES :
CS(=O)(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

Download SDS (MSDS)

Certificate of Analysis

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