CAY10571 is a cell permeable, reversible, and ATP-competitive sulfone analog of the p38 MAP kinase inhibitor SB 203580. Potently inhibits p38 kinase (IC50 = 30 nM) and inhibits IL-1 production in human monocytes (IC50 = 200 nM).
1. Lee, J.C., et al. 1994. Nature 372: 739-746. PMID: 7997261 2. Cuenda, A., et al. 1995. FEBS Lett. 364: 229-233. PMID: 7750577 3. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5: 49-64. PMID: 9043657
Soluble in DMSO (200 mg/ml), DMF (~50 mg/ml), and 1:3 DMF:PBS (pH 7.2) (~0.25 mg/ml).
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