Date published: 2025-9-5
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caveolin-1 Antibody (7C8) - Western Blotting - Image 377751
洞穴素-1 抗体 (7C8): sc-53564. CHO-K1 (A) 和 ARPE-19 (B) 全细胞裂解液中 caveolin-1 表达的 Western 印迹分析.
洞穴素-1 抗体 (7C8): sc-53564. CHO-K1 (A) 和 ARPE-19 (B) 全细胞裂解液中 caveolin-1 表达的 Western 印迹分析.

caveolin-1 抗体 (7C8): sc-53564

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说明书
  • caveolin-1 抗体 7C8 是小鼠单克隆 IgG2b κ，caveolin-1抗体, 在109篇文献中引用，规格为200 µg/ml
  • 针对rat来源的脂肪细胞的纯化Glut4囊泡
  • caveolin-1 抗体 (7C8) 推荐用于WB, IP, IF 和 FCM，检测mouse, rat, human， 以及在较小程度上，检测 hamster 来源的 caveolin-1
  • 抗caveolin-1抗体（7C8）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取caveolin-1 (7C8): sc-53564的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP是caveolin-1 Antibody (7C8) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与caveolin-1 Antibody (7C8) 搭配使用（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外Caveolin抗体，包括caveolin-3

caveolin-1 抗体（7C8）是一种小鼠单克隆 IgG2b kappa 轻链抗体，靶向 caveolin-1（也称 CAV1），它是洞穴（caveolae）的主要成分，洞穴是各种类型细胞质膜上的小内陷。抗 Caveolin-1 抗体 (7C8) 是针对大鼠脂肪细胞中纯化的 Glut4 囊泡而制备的，可通过免疫印迹 (WB)、免疫沉淀 (IP)、免疫荧光 (IF) 和流式细胞术 (FCM) 等应用检测小鼠、大鼠、人类以及仓鼠样本中的 Caveolin-1。Caveolin-1 在洞穴的形成和功能中起着至关重要的作用，洞穴参与了内吞、信号转导和脂质调节等过程。洞穴素-1 主要位于质膜，有助于洞穴的结构完整性，并参与信号分子（包括 G 蛋白偶联受体）的区隔。此外，洞穴素-1 还与多种细胞功能有关，如大分子的转运、通过壶状细胞摄取小分子以及调节胆固醇的平衡。Caveolin-1 单克隆抗体 (7C8) 有非共轭型和多种共轭型，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和各种 Alexa Fluor® 共轭物，为各种实验设置提供了灵活性。抗洞穴素-1 抗体 (7C8) 推荐用于研究洞穴在细胞生理学和病理学中的作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

caveolin-1 抗体 (7C8) 参考文献:

  1. [信：腰痛--鉴别诊断和手术治疗。对 A. Göb, S. Stotz, Münch.Wschr.116 (1974) 273].  |  Scheef, SE. 1975. MMW Munch Med Wochenschr. 117: 1359-60. PMID: 126375
  2. 洞穴素（Caveolin）是洞穴膜衣的蛋白质成分。  |  Rothberg, KG., et al. 1992. Cell. 68: 673-82. PMID: 1739974
  3. 3T3-L1 成纤维细胞分化为脂肪细胞时质膜的形态变化。  |  Fan, JY., et al. 1983. J Cell Sci. 61: 219-30. PMID: 6885939
  4. 从富含内皮细胞的来源中分离出的富含洞穴素的膜域的特征：对人类疾病的影响。  |  Lisanti, MP., et al. 1994. J Cell Biol. 126: 111-26. PMID: 7517942
  5. 上皮细胞中的VIP21/caveolin, 糖磷脂簇和糖基磷脂酰肌醇锚定蛋白的分拣。  |  Zurzolo, C., et al. 1994. EMBO J. 13: 42-53. PMID: 8306971
  6. 洞穴素-2 的鉴定, 序列和表达定义了洞穴素基因家族。  |  Scherer, PE., et al. 1996. Proc Natl Acad Sci U S A. 93: 131-5. PMID: 8552590
  7. 主要在肌肉中表达的洞穴素基因家族新成员洞穴素-3的分子克隆。  |  Tang, Z., et al. 1996. J Biol Chem. 271: 2255-61. PMID: 8567687
  8. src酪氨酸激酶对洞穴素的磷酸化。洞穴素的α-异构体在体内被v-Src选择性磷酸化。  |  Li, S., et al. 1996. J Biol Chem. 271: 3863-8. PMID: 8632005
  9. Caveolin-3在骨骼肌, 心肌和平滑肌细胞中的表达。Caveolin-3 是肌浆膜的组成部分，与肌营养不良蛋白和肌营养不良蛋白相关糖蛋白共同分化。  |  Song, KS., et al. 1996. J Biol Chem. 271: 15160-5. PMID: 8663016

订购信息

产品名称产品编号规格价格数量收藏夹

caveolin-1 抗体 (7C8)

sc-53564
200 µg/ml
$316.00

caveolin-1 (7C8): m-IgG Fc BP-HRP 套装

sc-525608
200 µg Ab; 10 µg BP
$354.00

caveolin-1 抗体 (7C8) AC

sc-53564 AC
500 µg/ml, 25% agarose
$416.00

caveolin-1 抗体 (7C8) HRP

sc-53564 HRP
200 µg/ml
$316.00

caveolin-1 抗体 (7C8) FITC

sc-53564 FITC
200 µg/ml
$330.00

caveolin-1 抗体 (7C8) PE

sc-53564 PE
200 µg/ml
$343.00

caveolin-1 抗体 (7C8) Alexa Fluor® 488

sc-53564 AF488
200 µg/ml
$357.00

caveolin-1 抗体 (7C8) Alexa Fluor® 546

sc-53564 AF546
200 µg/ml
$357.00

caveolin-1 抗体 (7C8) Alexa Fluor® 594

sc-53564 AF594
200 µg/ml
$357.00

caveolin-1 抗体 (7C8) Alexa Fluor® 647

sc-53564 AF647
200 µg/ml
$357.00

caveolin-1 抗体 (7C8) Alexa Fluor® 680

sc-53564 AF680
200 µg/ml
$357.00

caveolin-1 抗体 (7C8) Alexa Fluor® 790

sc-53564 AF790
200 µg/ml
$357.00

Please clarify what is the dilution of caveolin-1 Antibody (7C8) HRP ANTIBODY for IHC-P side. Thanks

Asked by: Dr Kaushlendra
Thank you for your question. We recommend 1:50-1:500. https://www.scbt.com/resources/protocols/immunoperoxidase-staining
Answered by: BlakeJ
Date published: 2023-06-23

I just ordered the CAVEOLIN-1 ANTIBODY (7C8), but I'm not sure this one works for our mouse retina tissue samples, Can I hold this order now?

Asked by: susanz
Thank you for your question. Please contact our Customer Care Department directly to request to cancel or hold any orders. This antibody is recommended for detection of caveolin-1 in mouse samples. We have not specifically tested it for detection in retina tissue.
Answered by: Technical Support
Date published: 2020-07-07

Can this antibody be used for IHC of tissue sections frozen in OCT? I am trying to stain carotid artery vessel sections using this antibody

Asked by: harding
This primary antibody is recommended and warrantied for IF (immunofluorescent staining of fresh or frozen tissues or cells fixed in methanol or acetone), however we are still gathering data to show on our website. Check back for updates!
Answered by: Technical Support
Date published: 2019-01-26

I would like to use this antibody to detect caveolin-1 in my porcine samples. Will it work?

Asked by: Cweed
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 13
Date published: 2019-03-20

For your product, Caveolin-1 antibody (7C8), which residues does this bind to? I need an antibody for the c-terminus of Caveolin, and this is listed as the replacement for the discontinued 82-178 Cav-1 antibody. Thanks!

Asked by: Phil Esempio
Thank you for your question. The exact epitope recognized by this mouse monoclonal antibody, caveolin-1 (7C8): sc-53564, has not been characterized. However, it is known to recognize between amino acids 32 and the C-terminus of caveolin-1.
Answered by: Technical Support
Date published: 2016-09-22
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Rated 4 out of 5 by from Good antibodies for IF and WBThe Cav1 antibody is good for immunostaining and western blot in mouse lung tissue.
Date published: 2022-07-15
Rated 5 out of 5 by from Muy buen resultado para microscopia confocalCompré este producto para probar stainings en microscopia confocal con muy buen resultado.
Date published: 2022-04-25
Rated 4 out of 5 by from good antibodyThe antibody was used in primary human cells and worked fine with dilution of 1:250.
Date published: 2020-10-02
Rated 3 out of 5 by from ImmunoflourescenceIn IF experiments, I tried it in placenta cells and it has a great background. It is better for WB-
Date published: 2018-05-29
Rated 5 out of 5 by from WBWe used Caveolin-1 (7C8) antibody for WB in Human SCC25 cells, and it worked well. Just remember use 1/250 to get good signal. We used 1/500 and it was a bit weak. We used anti-mouse IgG.
Date published: 2018-03-28
Rated 1 out of 5 by from Antibody did not work on Western BlotI did a Western Blot to compare this antibody with caveolin-1 Antibody (N-20): sc-894. While I had a very nice signal of discontinued antibody, the new monoclonal one did not give any signal even at dilution 1:200, though the loading controls looked well.
Date published: 2018-02-16
Rated 4 out of 5 by from Good for western blotThe antibody was tested by western blot in lipid rafts fractions from endothelial cells. It works well.
Date published: 2018-01-31
Rated 1 out of 5 by from Not good for western blottingGot a sample antibody and even at 1:100 with perfect GAPDH and a positive control was not successful for western blotting. Got one from source biosciences that worked fantastically well using the same samples at 1:500.
Date published: 2018-01-15
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caveolin-1 抗体 (7C8) is rated 4.1 out of 5 by 34.
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