Date published: 2025-10-29

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Cathepsin inhibitor peptide

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Alternate Names:
Cathepsin inhibitor I; Z-FG-NHO-Bz; CATI -1
Application:
Cathepsin inhibitor peptide is a cysteine protease inhibitor
Purity:
≥90% (HPLC)
Molecular Weight:
475.49
Molecular Formula:
C26H25N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cathepsin inhibitor peptide is a vital tool in scientific research, particularly in elucidating the roles of cathepsins in cellular processes. This peptide, by virtue of its ability to inhibit cathepsin activity, serves as a potent modulator of intracellular proteolytic pathways. Through its interaction with specific cathepsin isoforms, it offers insights into proteolytic cascades implicated in various physiological and pathological conditions. Research employing this inhibitor has uncovered its involvement in diverse cellular processes, including protein turnover, antigen processing, and extracellular matrix remodeling. Moreover, studies utilizing this peptide have shed light on the complex interplay between cathepsins and other cellular components, unraveling their significance in cellular homeostasis and disease progression. Furthermore, the application of cathepsin inhibitor peptide has extended to investigations concerning cancer metastasis, neurodegenerative disorders, and immune responses, where cathepsin dysregulation is implicated. Through precise modulation of cathepsin activity, this peptide offers a nuanced approach to dissecting the mechanistic underpinnings of various cellular phenomena, thereby advancing our understanding of fundamental biological processes and paving the way for the development of targeted interventions.


Cathepsin inhibitor peptide References

  1. Glucocorticoids engage different signal transduction pathways to induce apoptosis in thymocytes and mature T cells.  |  Wang, D., et al. 2006. J Immunol. 176: 1695-702. PMID: 16424199
  2. Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.  |  Alao, JP., et al. 2006. Mol Cancer. 5: 8. PMID: 16504004
  3. A role for the intracellular protease calpain in the activation of store-operated calcium entry in human platelets.  |  Harper, AG. and Sage, SO. 2007. Cell Calcium. 41: 169-78. PMID: 16884770
  4. Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathway.  |  Miao, Q., et al. 2008. J Biol Chem. 283: 8218-28. PMID: 18211899
  5. Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B.  |  Hwang, SY., et al. 2009. Biochim Biophys Acta. 1793: 1656-68. PMID: 19748528
  6. Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.  |  Baietti, MF., et al. 2012. Nat Cell Biol. 14: 677-85. PMID: 22660413
  7. Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP⁺-induced apoptosis but not rotenone or 6-hydroxydopamine toxicity.  |  Garcia-Garcia, A., et al. 2013. Toxicol Sci. 136: 166-82. PMID: 23997112
  8. Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10.  |  Murphy, N., et al. 2014. Neuromolecular Med. 16: 205-15. PMID: 24197756
  9. VPS52 induces apoptosis via cathepsin D in gastric cancer.  |  Zhang, J., et al. 2017. J Mol Med (Berl). 95: 1107-1116. PMID: 28791438
  10. Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma.  |  Locquet, MA., et al. 2021. Sci Rep. 11: 10609. PMID: 34011952

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cathepsin inhibitor peptide, 1 mg

sc-3130
1 mg
$115.00