Molecular structure of Carboxy-PTIO, potassium salt, CAS Number: 148819-94-7
Carboxy-PTIO, potassium salt (CAS 148819-94-7)
See product citations (10)
Alternate Names:
Carboxy-PTIO, potassium salt also known as 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt
Application:
Carboxy-PTIO, potassium salt is a water soluble and stable nitric oxide radical scavenger which reacts with nitric oxide
CAS Number:
148819-94-7
Purity:
≥98%
Molecular Weight:
315.39
Molecular Formula:
C14H16N2O4•K
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Carboxy-PTIO, potassium salt reacts with nitric oxide to form carboxy-PTI derivatives which in turn inhibits NOS (nitric oxide synthase). Carboxy-PTIO, potassium salt is a potassium salt shown to be a stable imidazolineoxyl N-oxide radical compound. Studies have indicated that Carboxy-PTIO, potassium salt is a nitric oxide antagonist and as a result, causes concentration-dependent reductions of murine aortic relaxation. Further studies suggest that at concentrations of 300muM or more Carboxy-PTIO, potassium salt actually slightly enhances relaxation elicited by nitrergic nerve stimulation.
Carboxy-PTIO, potassium salt (CAS 148819-94-7) References
- Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ion. | Wanstall, JC., et al. 2001. Br J Pharmacol. 134: 463-72. PMID: 11588100
- Role of nitric oxide in brain regions related to defensive reactions. | Guimarães, FS., et al. 2005. Neurosci Biobehav Rev. 29: 1313-22. PMID: 16095696
- Molecular mechanisms and therapeutic strategies of chronic renal injury: physiological role of angiotensin II-induced oxidative stress in renal medulla. | Mori, T., et al. 2006. J Pharmacol Sci. 100: 2-8. PMID: 16404134
- Inhibition of staphylococcal biofilm formation by nitrite. | Schlag, S., et al. 2007. J Bacteriol. 189: 7911-9. PMID: 17720780
- Nitric oxide production and its functional link with OIPK in tobacco defense response elicited by chitooligosaccharide. | Zhang, H., et al. 2011. Plant Cell Rep. 30: 1153-62. PMID: 21336582
- Label-free quantitative proteomics analysis of cotton leaf response to nitric oxide. | Meng, Y., et al. 2011. J Proteome Res. 10: 5416-32. PMID: 22029526
- S-sulfhydration/desulfhydration and S-nitrosylation/denitrosylation: a common paradigm for gasotransmitter signaling by H2S and NO. | Lu, C., et al. 2013. Methods. 62: 177-81. PMID: 23811297
- Lipopolysaccharide-induced cross-tolerance against renal ischemia-reperfusion injury is mediated by hypoxia-inducible factor-2α-regulated nitric oxide production. | He, K., et al. 2014. Kidney Int. 85: 276-88. PMID: 24025643
- Rapid NOS-1-derived nitric oxide and peroxynitrite formation act as signaling agents for inducible NOS-2 expression in vascular smooth muscle cells. | Scheschowitsch, K., et al. 2015. Pharmacol Res. 100: 73-84. PMID: 26253183
- Dorsal hippocampus cholinergic and nitrergic neurotransmission modulates the cardiac baroreflex function in rats. | Ferreira-Junior, NC., et al. 2020. Eur J Neurosci. 51: 991-1010. PMID: 31626713
- A new nitric oxide scavenger, imidazolineoxyl N-oxide derivative, and its effects in pathophysiology and microbiology. | Maeda, H., et al. 1995. Curr Top Microbiol Immunol. 196: 37-50. PMID: 7543398
- Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies. | Tsunoda, R., et al. 1994. Eur J Pharmacol. 262: 55-63. PMID: 7813579
- Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction. | Akaike, T., et al. 1993. Biochemistry. 32: 827-32. PMID: 8422387
- Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. | Rand, MJ. and Li, CG. 1995. Br J Pharmacol. 116: 1906-10. PMID: 8528578
- Superoxide anions, free-radical scavengers, and nitrergic neurotransmission. | Gibson, A. and Lilley, E. 1997. Gen Pharmacol. 28: 489-93. PMID: 9147013
Inhibitor of:
Enzyme, and NOS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Carboxy-PTIO, potassium salt, 10 mg | sc-202985 | 10 mg | $97.00 | |||
Carboxy-PTIO, potassium salt, 50 mg | sc-202985A | 50 mg | $305.00 | |||
Carboxy-PTIO, potassium salt, 250 mg | sc-202985B | 250 mg | $969.00 |