Molecular structure of Canrenone, CAS Number: 976-71-6
Canrenone (CAS 976-71-6)
See product citations (3)
Alternate Names:
Phanurane; Aldadiene; Luvion
Application:
Canrenone is an inhibitor of aldosterone biosynthesis and ouabain
CAS Number:
976-71-6
Purity:
≥97%
Molecular Weight:
340.46
Molecular Formula:
C22H28O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Canrenone (also known as canrenoic acid) is an active metabolite of spironolactone that acts as an MCR antagonist, inhibiting aldosterone biosynthesis. It also blocks ouabain effects. Furthermore, it is a potent inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which is a key enzyme involved in the metabolism of glucocorticoids.Canrenone is a steroidal compound that is used in scientific research as a tool to study biochemical and physiological effects of steroids. In addition, it has been found to have anti-inflammatory, anti-tumor, and anti-atherosclerotic properties.
Canrenone (CAS 976-71-6) References
- Effects of canrenone on aorta and right ventricle of the rat. | Cargnelli, G., et al. 2001. J Cardiovasc Pharmacol. 37: 540-7. PMID: 11336105
- Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. | Caligiuri, A., et al. 2003. Gastroenterology. 124: 504-20. PMID: 12557155
- Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshold in experimental heart failure. | Cittadini, A., et al. 2003. Cardiovasc Res. 58: 555-64. PMID: 12798428
- Effect of canrenone on the digitalis site of Na+/K(+)-ATPase in human placental membranes and in erythrocytes. | Balzan, S., et al. 2003. J Cardiovasc Pharmacol. 42: 32-6. PMID: 12827023
- A new turbidometric digoxin immunoassay on the ADVIA 1650 analyzer is free from interference by spironolactone, potassium canrenoate, and their common metabolite canrenone. | Datta, P. and Dasgupta, A. 2003. Ther Drug Monit. 25: 478-82. PMID: 12883233
- Effect of spironolactone, potassium canrenoate, and their common metabolite canrenone on Dimension Vista Digoxin Assay. | Dasgupta, A. and Johnson, MJ. 2010. J Clin Lab Anal. 24: 413-7. PMID: 21089173
- Do canrenone and 6,7-dihydroxylated derivatives compete with ouabain at the same site on Na,K-ATPase? | Tal, DM. and Karlish, SJ. 1988. Mol Pharmacol. 34: 245-9. PMID: 2843743
- Hypotensive action of canrenone in a model of hypertension where ouabain-like factors are present. | De Mendonca, M., et al. 1985. J Hypertens Suppl. 3: S73-5. PMID: 2856827
- Canrenone on cardiovascular mortality in congestive heart failure: CanrenOne eFFects on cardiovascular mortality in patiEnts with congEstIve hearT failure: The COFFEE-IT study. | Derosa, G., et al. 2019. Pharmacol Res. 141: 46-52. PMID: 30502530
- Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease. | Chung, EY., et al. 2020. Cochrane Database Syst Rev. 10: CD007004. PMID: 33107592
- Canrenone Restores Vasorelaxation Impaired by Marinobufagenin in Human Preeclampsia. | Agalakova, NI., et al. 2022. Int J Mol Sci. 23: PMID: 35328757
- Canrenone as a partial agonist at the digitalis receptor site of sodium-potassium-activated adenosine triphosphatase. | Finotti, P. and Palatini, P. 1981. J Pharmacol Exp Ther. 217: 784-90. PMID: 6262496
- Small doses of canrenone block the effects of ouabain on the mechanical activity of the heart and vessels of the rat. | Vassallo, PF., et al. 1998. J Cardiovasc Pharmacol. 32: 679-85. PMID: 9821839
Inhibitor of:
Aldosterone, Enzyme, and MCR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Canrenone, 1 g | sc-205616 | 1 g | $94.00 | |||
Canrenone, 5 g | sc-205616A | 5 g | $333.00 |