CaM Kinase II (290-309), Calmodulin Antagonist CAS: 115044-69-4
MF: C103H185N31O24S
MW: 2273.8
A potent CaMKII inhibitor.

CaM Kinase II (290-309), Calmodulin Antagonist (CAS 115044-69-4)

CaM Kinase II (290-309), Calmodulin Antagonist | CAS 115044-69-4 is rated 5.0 out of 5 by 1.
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Alternate Names: Ca2+/calmodulin-dependent protein kinase II (290-309)
Application: CaM Kinase II (290-309), Calmodulin Antagonist is a potent CaMKII inhibitor
CAS Number: 115044-69-4
Purity: >97%
Molecular Weight: 2273.8
Molecular Formula: C103H185N31O24S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

CaM Kinase II (290-309), Calmodulin Antagonist is a potent, synthetic peptide inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II), which was derived from the cDNA sequence of the rat brain 50-kDa alpha subunit. The use of this inhibitory peptide elucidated the calmodulin binding and inhibitory domains, as well as the initial autophosphorylation site (Thr286) of CaMKII with an IC50 of 52 nM. This peptide product binds CaM (calmodulin) tightly and inhibits additional calmodulin-requiring enzymes, such as PDE (phosphodiesterase) and PP2B (calcineurin). Investigators used this product in STC-1 cells to study the regulation of L-type calcium channels and found the inhibitory peptide to block whole cell calcium currents. Additional research in T84 cells showed that this peptide reduced chloride current by approximately 70% without effect on the channels in parotid acinar cells.


References

1. Payne, M.E., et al. 1988. J. Biol. Chem. 263: 7190-7195. PMID: 2835367
2. Colbran, R.J., et al. 1989. J. Biol. Chem. 264: 4800-4804. PMID: 2538462
3. Mukherji, S., et al. 1995. J. Biol. Chem. 270: 14062-14067. PMID: 7775466
4. Arreola, J., et al. 1998. Am. J. Physiol. 274: C161-C166. PMID: 9458724
5. Basavappa, S., et al. 1999. Biochem. Biophys. Res. Commun. 254: 699-702. PMID: 9920804
6. Ichida, S., et al. 2000. Neurochem. Res. 25: 1629-1635. PMID: 11152392

Physical State :
Solid
Sequence :
Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala
Solubility :
Soluble in water.
Storage :
Store at -20° C
IC50 :
activation of calmodulin-dependent protein kinase II: IC50 = 52 nM ; calmodulin dependent phosphodiesterase: IC50 = 1.1 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
22114573
MDL Number :
MFCD00076719
SMILES :
CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CC(=O)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Tsunoda K; et al Tsunoda K; et al. (PubMed ID: 26418512) determined that CaM Kinase II (290-309), Calmodulin Antagonist inhibited nicotine-mediated IL-8 secretion in oral squamous cell carcinoma cell. -SCBT Publication Review
Date published: 2015-06-29
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