CalciFluor™ Fluo-8, AM has been developed to improve cell loading and calcium response while maintaining the convenient Fluo-3 and Fluo-4 spectral wavelength of maximum excitation at ~490 nm and maximum emission at ~520 nm. Similarly to Fluo-4, AM, the anionic carboxy groups are protected with acetoxy methyl esters allowing membrane permeability. These are subsequently removed by intracellular esterases allowing Ca2+ detection. However CalciFluor™ Fluo-8, AM is efficiently loaded into cells at room temperature (whereas Fluo-3 and Fluo-4 require much more harsh loading conditions), and CalciFluor™ Fluo-8, AM is 2 times brighter than Fluo-4 and 4 times brighter than Fluo-3. These features, as well as a lower price, make CalciFluor™ Fluo-8, AM a superior calcium indicator.
See how others have used CalciFluor Fluo-8, AM (CAS 1345980-40-6). Click on the entry to view the PubMed entry .
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