Cables2 Antibody (D-6): sc-376272
- Cables2 Antibody (D-6) is a mouse monoclonal IgG1 κ Cables2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 85-119 within an internal region of Cables2 of human origin
- Cables2 Antibody (D-6) is recommended for detection of Cables2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Cables2 Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Cables2 Antibody (D-6) for WB and IHC(P) applications. This reagent is now offered in a bundle with Cables2 Antibody (D-6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Cables2 Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cables2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Cables2 Antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cables2, also known as Cdk5 and ABL1 enzyme substrate 2 or Ik3-2, is a 478 amino acid protein that is ubiquitously expressed and features a C-terminal cyclin box-containing domain, classifying Cables2 within the cyclin protein superfamily. Cables2 plays a crucial role in cell cycle regulation and apoptosis, particularly through interactions with cyclin-dependent kinases (CDKs) and c-Abl, which are vital for maintaining cellular homeostasis. Notably, Cables2 forms a trimolecular complex with Cdk5 and c-Abl, enhancing apoptosis induced by p53 overexpression, which suggests a potential function as a tumor suppressor due to association with chromosomal loss of heterozygosity in certain cancers. Furthermore, Cables2 shares 78% sequence similarity with Cables, particularly in the cyclin box-containing domain, but Cables2 also possesses an N-terminal region that enhances both p53-mediated and p53-independent cell death, indicating broader implications in tumor suppression and cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cables2 Antibody (D-6) References:
- ik3-1/Cables is associated with Trap and Pctaire2. | Yamochi, T., et al. 2001. Biochem Biophys Res Commun. 286: 1045-50. PMID: 11527406
- Differential effect of ik3-1/cables on p53- and p73-induced cell death. | Tsuji, K., et al. 2002. J Biol Chem. 277: 2951-7. PMID: 11706030
- ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). | Yamochi, T., et al. 2001. Eur J Biochem. 268: 6076-82. PMID: 11733001
- ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. | Sato, H., et al. 2002. Biochim Biophys Acta. 1574: 157-63. PMID: 11955625
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg, RL., et al. 2002. Proc Natl Acad Sci U S A. 99: 16899-903. PMID: 12477932
- ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways. | Matsuoka, M., et al. 2003. Biochem Biophys Res Commun. 312: 520-9. PMID: 14637168
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cables2 Antibody (D-6) | sc-376272 | 200 µg/ml | $316.00 | |||
Cables2 Antibody (D-6): m-IgGκ BP-HRP Bundle | sc-522904 | 200 µg Ab, 40 µg BP | $354.00 | |||
Cables2 Antibody (D-6) AC | sc-376272 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Cables2 Antibody (D-6) HRP | sc-376272 HRP | 200 µg/ml | $316.00 | |||
Cables2 Antibody (D-6) FITC | sc-376272 FITC | 200 µg/ml | $330.00 | |||
Cables2 Antibody (D-6) PE | sc-376272 PE | 200 µg/ml | $343.00 | |||
Cables2 Antibody (D-6) Alexa Fluor® 488 | sc-376272 AF488 | 200 µg/ml | $357.00 | |||
Cables2 Antibody (D-6) Alexa Fluor® 546 | sc-376272 AF546 | 200 µg/ml | $357.00 | |||
Cables2 Antibody (D-6) Alexa Fluor® 594 | sc-376272 AF594 | 200 µg/ml | $357.00 | |||
Cables2 Antibody (D-6) Alexa Fluor® 647 | sc-376272 AF647 | 200 µg/ml | $357.00 | |||
Cables2 Antibody (D-6) Alexa Fluor® 680 | sc-376272 AF680 | 200 µg/ml | $357.00 | |||
Cables2 Antibody (D-6) Alexa Fluor® 790 | sc-376272 AF790 | 200 µg/ml | $357.00 | |||
Cables2 (D-6) Neutralizing Peptide | sc-376272 P | 100 µg/0.5 ml | $68.00 |